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Essawy SS, Abo-Elmatty DM, Ghazy NM, et al. Antioxidant and anti-inflammatory effects of Marrubium alysson extracts in high cholesterol-fed rabbits. Saudi Pharm J. 2013;22(5):472-82doi: 10.1016/j.jsps.2013.12.004.
Essawy, S. S., Abo-Elmatty, D. M., Ghazy, N. M., Badr, J. M., & Sterner, O. (2014). Antioxidant and anti-inflammatory effects of Marrubium alysson extracts in high cholesterol-fed rabbits. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 22(5), 472-82. https://doi.org/10.1016/j.jsps.2013.12.004
Essawy, Soha S, et al. "Antioxidant and anti-inflammatory effects of Marrubium alysson extracts in high cholesterol-fed rabbits." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 22,5 (2014): 472-82. doi: https://doi.org/10.1016/j.jsps.2013.12.004
Essawy SS, Abo-Elmatty DM, Ghazy NM, Badr JM, Sterner O. Antioxidant and anti-inflammatory effects of Marrubium alysson extracts in high cholesterol-fed rabbits. Saudi Pharm J. 2014 Nov;22(5):472-82. doi: 10.1016/j.jsps.2013.12.004. Epub 2013 Dec 21. PMID: 25473336; PMCID: PMC4246394.
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Saudi Pharm J. 2014 Nov;22(5):472-82. doi: 10.1016/j.jsps.2013.12.004. Epub 2013 Dec 21.

Antioxidant and anti-inflammatory effects of Marrubium alysson extracts in high cholesterol-fed rabbits.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Soha S Essawy, Dina M Abo-Elmatty, Nabila M Ghazy, Jihan M Badr, Olov Sterner

Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
  2. Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
  3. Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
  4. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
  5. Department of Organic Chemistry 2, Lund University, P.O. Box 124, S-21100 Lund, Sweden.

PMID: 25473336 PMCID: PMC4246394 DOI: 10.1016/j.jsps.2013.12.004

Abstract

The antioxidant and anti-inflammatory effects of hexane (HEXA), chloroform (CHLORO), ethyl acetate (EA) and total alcoholic (T. ALCOH) extracts of Marrubium alysson in hypercholesterolemic-fed rabbits were evaluated. Hypercholesterolemia was induced in male rabbits by high cholesterol diet (HCD) (350 mg/kg) for 8 weeks. Hypercholesterolemic rabbits were allocated into groups, treated with simvastatin (SIM 5 mg/kg), different extracts of M. alysson at two doses of 250, 500 mg/kg. A normal control group and an HCD control one were used for comparison. Lipid profile, as well as oxidized low density lipoprotein-cholesterol (ox-LDL-C), myeloperoxidase activity (MPO) and superoxide anion production (O2•(-)), C-reactive protein (CRP) and monocyte chemoattractant protein-1 (MCP-1) were also evaluated. In addition, histological examination of ascending aorta was performed. We found dyslipidemia associated with significant increases in ox-LDL-C 123.5 ± 9.8 nmol MDA/mg non-HDL, MPO activity 0.08 ± 0.05 U/100 mg tissue and O2•(-) production 3.5 ± 0.3 nmol cytochrome C reduced/min/g tissue × 10(-4) in hypercholerterolemic rabbits. In addition, there was a significant increase in CRP 6.6 ± 0.49 μmol/L and MCP-1 190.9 ± 6.4 pg/ml and its mRNA expression in HCD. Intima appeared thick with thick plaques surrounding the intima and luminal narrowing. SIM, EA and HEXA extracts of M. alysson had lipid lowering effect, decrease in ox-LDL-C, MPO, O2•(-), CRP and MCP-1 mRNA expression with improvement of the pathological picture. M. alysson enhanced the stability of plaque, had lipid lowering, anti-inflammatory and antioxidant activities.

Keywords: Anti-inflammatory; Antioxidant; Hypercholesterolemia; Marrubium alysson

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