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Mahasneh T, Harrington Z, Williamson J, et al. Intravascular large B-cell lymphoma complicated by invasive pulmonary aspergillosis: a rare presentation. Respirol Case Rep. 2014;2(2):67-9doi: 10.1002/rcr2.51.
Mahasneh, T., Harrington, Z., Williamson, J., Alkhawaja, D., Duflou, J., & Shin, J. S. (2014). Intravascular large B-cell lymphoma complicated by invasive pulmonary aspergillosis: a rare presentation. Respirology case reports, 2(2), 67-9. https://doi.org/10.1002/rcr2.51
Mahasneh, Tamadur, et al. "Intravascular large B-cell lymphoma complicated by invasive pulmonary aspergillosis: a rare presentation." Respirology case reports vol. 2,2 (2014): 67-9. doi: https://doi.org/10.1002/rcr2.51
Mahasneh T, Harrington Z, Williamson J, Alkhawaja D, Duflou J, Shin JS. Intravascular large B-cell lymphoma complicated by invasive pulmonary aspergillosis: a rare presentation. Respirol Case Rep. 2014 Jun;2(2):67-9. doi: 10.1002/rcr2.51. Epub 2014 Feb 25. PMID: 25473570; PMCID: PMC4184509.
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Respirol Case Rep. 2014 Jun;2(2):67-9. doi: 10.1002/rcr2.51. Epub 2014 Feb 25.

Intravascular large B-cell lymphoma complicated by invasive pulmonary aspergillosis: a rare presentation.

Respirology case reports

Tamadur Mahasneh, Zinta Harrington, Jonathan Williamson, Darweesh Alkhawaja, Jo Duflou, Joo-Shik Shin

Affiliations

  1. Department of Anatomical Pathology, School of Medicine, University of Western Sydney Sydney, New South Wales, Australia.
  2. Department of Respiratory Medicine, Liverpool Hospital, University of New South Wales Sydney, New South Wales, Australia.
  3. Department of Surgery, Nepean Hospital, University of Sydney Sydney, New South Wales, Australia.
  4. Department of Forensic Medicine, University of Sydney Sydney, New South Wales, Australia.

PMID: 25473570 PMCID: PMC4184509 DOI: 10.1002/rcr2.51

Abstract

We describe a patient with persisting fevers, a progressive pulmonary infiltrate, and high levels of serum lactate dehydrogenase. No underlying cause for these changes was found prior to her death despite extensive investigations. Postmortem tissue revealed invasive pulmonary aspergillosis and subsequent brain examination revealed vascular changes in keeping with intravascular large B-cell lymphoma (IVLBCL). On review, subtle yet extensive lymphomatous infiltrates involved the vasculature of multiple other organs, including the lungs. Aspergillosis is a relatively rare presenting feature of lymphoproliferative disorders, and IVLBCL is a rare subtype of diffuse large B-cell non-Hodgkin's lymphoma with, to our knowledge, very few case reports to date. Lymphoma should be considered in patients presenting with pneumonitis with bilateral lung infiltrates on imaging, with a high serum level of lactate dehydrogenase.

Keywords: Cough; intravascular lymphoma; lactate dehydrogenase; pulmonary aspergillosis; pyrexia

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