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Murugan A, Zeravcic Z, Brenner MP, et al. Multifarious assembly mixtures: systems allowing retrieval of diverse stored structures. Proc Natl Acad Sci U S A. 2014;112(1):54-9doi: 10.1073/pnas.1413941112.
Murugan, A., Zeravcic, Z., Brenner, M. P., & Leibler, S. (2015). Multifarious assembly mixtures: systems allowing retrieval of diverse stored structures. Proceedings of the National Academy of Sciences of the United States of America, 112(1), 54-9. https://doi.org/10.1073/pnas.1413941112
Murugan, Arvind, et al. "Multifarious assembly mixtures: systems allowing retrieval of diverse stored structures." Proceedings of the National Academy of Sciences of the United States of America vol. 112,1 (2015): 54-9. doi: https://doi.org/10.1073/pnas.1413941112
Murugan A, Zeravcic Z, Brenner MP, Leibler S. Multifarious assembly mixtures: systems allowing retrieval of diverse stored structures. Proc Natl Acad Sci U S A. 2015 Jan 06;112(1):54-9. doi: 10.1073/pnas.1413941112. Epub 2014 Dec 22. PMID: 25535383; PMCID: PMC4291664.
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Proc Natl Acad Sci U S A. 2015 Jan 06;112(1):54-9. doi: 10.1073/pnas.1413941112. Epub 2014 Dec 22.

Multifarious assembly mixtures: systems allowing retrieval of diverse stored structures.

Proceedings of the National Academy of Sciences of the United States of America

Arvind Murugan, Zorana Zeravcic, Michael P Brenner, Stanislas Leibler

Affiliations

  1. School of Engineering and Applied Sciences and Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge, MA 02138; [email protected] [email protected].
  2. School of Engineering and Applied Sciences and Kavli Institute for Bionano Science and Technology, Harvard University, Cambridge, MA 02138;
  3. Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540; and Laboratory of Living Matter, The Rockefeller University, New York, NY 10065.

PMID: 25535383 PMCID: PMC4291664 DOI: 10.1073/pnas.1413941112

Abstract

Self-assembly materials are traditionally designed so that molecular or mesoscale components form a single kind of large structure. Here, we propose a scheme to create "multifarious assembly mixtures," which self-assemble many different large structures from a set of shared components. We show that the number of multifarious structures stored in the solution of components increases rapidly with the number of different types of components. However, each stored structure can be retrieved by tuning only a few parameters, the number of which is only weakly dependent on the size of the assembled structure. Implications for artificial and biological self-assembly are discussed.

Keywords: complex materials; programmed assembly; stored structures

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