Display options
Cite
Lee YJ, Son YM, Gu MJ, et al. Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells. J Ginseng Res. 2014;39(1):29-37doi: 10.1016/j.jgr.2014.07.003.
Lee, Y. J., Son, Y. M., Gu, M. J., Song, K. D., Park, S. M., Song, H. J., Kang, J. S., Woo, J. S., Jung, J. H., Yang, D. C., Han, S. H., & Yun, C. H. (2015). Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells. Journal of ginseng research, 39(1), 29-37. https://doi.org/10.1016/j.jgr.2014.07.003
Lee, Yeo Jin, et al. "Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells." Journal of ginseng research vol. 39,1 (2015): 29-37. doi: https://doi.org/10.1016/j.jgr.2014.07.003
Lee YJ, Son YM, Gu MJ, Song KD, Park SM, Song HJ, Kang JS, Woo JS, Jung JH, Yang DC, Han SH, Yun CH. Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells. J Ginseng Res. 2015 Jan;39(1):29-37. doi: 10.1016/j.jgr.2014.07.003. Epub 2014 Aug 07. PMID: 25535474; PMCID: PMC4268565.
Copy Download .nbib Format: NLM
Share it on

J Ginseng Res. 2015 Jan;39(1):29-37. doi: 10.1016/j.jgr.2014.07.003. Epub 2014 Aug 07.

Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells.

Journal of ginseng research

Yeo Jin Lee, Young Min Son, Min Jeong Gu, Ki-Duk Song, Sung-Moo Park, Hyo Jin Song, Jae Sung Kang, Jong Soo Woo, Jee Hyung Jung, Deok-Chun Yang, Seung Hyun Han, Cheol-Heui Yun

Affiliations

  1. Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Korea.
  2. Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Korea ; Center for Food and Bioconvergence, Seoul National University, Seoul, Korea.
  3. College of Pharmacy, Pusan National University, Busan, Korea.
  4. Korean Ginseng Center and Ginseng Genetic Resource Bank, Kyung Hee University, Kyunggi-do, Seoul, Korea.
  5. Department of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, Seoul National University, Seoul, Korea.

PMID: 25535474 PMCID: PMC4268565 DOI: 10.1016/j.jgr.2014.07.003

Abstract

BACKGROUND: Panax ginseng (i.e., ginseng) root is extensively used in traditional oriental medicine. It is a modern pharmaceutical reagent for preventing various human diseases such as cancer. Ginsenosides-the major active components of ginseng-exhibit immunomodulatory effects. However, the mechanism and function underlying such effects are not fully elucidated, especially in human monocytes and dendritic cells (DCs).

METHODS: We investigated the immunomodulatory effect of ginsenosides from Panax ginseng root on CD14(+) monocytes purified from human adult peripheral blood mononuclear cells (PBMCs) and on their differentiation into DCs that affect CD4(+) T cell activity.

RESULTS: After treatment with ginsenoside fractions, monocyte levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 increased through phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and c-Jun N-terminal kinase (JNK), but not p38 mitogen-activated protein kinase (MAPK). After treatment with ginsenoside fractions, TNF-α production and phosphorylation of ERK1/2 and JNK decreased in lipopolysaccharide (LPS)-sensitized monocytes. We confirmed that DCs derived from CD14(+) monocytes in the presence of ginsenoside fractions (Gin-DCs) contained decreased levels of the costimulatory molecules CD80 and CD86. The expression of these costimulatory molecules decreased in LPS-treated DCs exposed to ginsenoside fractions, compared to their expression in LPS-treated DCs in the absence of ginsenoside fractions. Furthermore, LPS-treated Gin-DCs could not induce proliferation and interferon gamma (IFN-γ) production by CD4(+) T cells with the coculture of Gin-DCs with CD4+ T cells.

CONCLUSION: These results suggest that ginsenoside fractions from the ginseng root suppress cytokine production and maturation of LPS-treated DCs and downregulate CD4(+) T cells.

Keywords: CD14+ monocytes; CD4+ T cells; Panax ginseng; dendritic cells; ginsenosides

References

  1. J Immunol. 1996 Nov 1;157(9):3850-9 - PubMed
  2. Br J Pharmacol. 2009 Apr;156(7):1136-46 - PubMed
  3. J Exp Med. 1968 Sep 1;128(3):415-35 - PubMed
  4. Fitoterapia. 2011 Sep;82(6):911-9 - PubMed
  5. Int J Mol Sci. 2010;11(12):4916-31 - PubMed
  6. Am J Chin Med. 1995;23(3-4):279-87 - PubMed
  7. Adv Exp Med Biol. 1995;378:75-8 - PubMed
  8. Mutagenesis. 2005 Jul;20(4):237-43 - PubMed
  9. Arch Pharm Res. 2011 Apr;34(4):681-5 - PubMed
  10. Mediators Inflamm. 1992;1(6):411-7 - PubMed
  11. Immunity. 1998 Sep;9(3):325-36 - PubMed
  12. Am Fam Physician. 2003 Oct 15;68(8):1539-42 - PubMed
  13. J Immunol. 1977 Jan;118(1):21-7 - PubMed
  14. Eur J Immunol. 2011 Feb;41(2):413-24 - PubMed
  15. Annu Rev Immunol. 2003;21:685-711 - PubMed
  16. Cell Tissue Kinet. 1972 Jul;5(4):311-7 - PubMed
  17. Biochem Biophys Res Commun. 2008 Nov 21;376(3):599-604 - PubMed
  18. Int Arch Allergy Immunol. 2004 Feb;133(2):113-20 - PubMed
  19. Phytochemistry. 2008 Jan;69(1):218-24 - PubMed
  20. Planta Med. 2006 Jun;72 (7):627-33 - PubMed
  21. Acta Pharmacol Sin. 2000 Sep;21(9):792-6 - PubMed
  22. Clin Immunol. 2012 Mar;142(3):332-42 - PubMed
  23. Biochem Pharmacol. 1999 Dec 1;58(11):1685-93 - PubMed
  24. J Immunol. 2008 Jun 15;180(12):8286-98 - PubMed
  25. Am J Chin Med. 2008;36(2):329-41 - PubMed
  26. Immunology. 2005 Feb;114(2):235-45 - PubMed

Publication Types