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Karimifar M, Moussavi H, Babaei M, et al. The association of immunoglobulin A, immunoglobulin G and anti-cyclic citrullinated peptide antibodies with disease activity in seronegative rheumatoid arthritis patients. J Res Med Sci. 2014;19(9):823-6
Karimifar, M., Moussavi, H., Babaei, M., & Akbari, M. (2014). The association of immunoglobulin A, immunoglobulin G and anti-cyclic citrullinated peptide antibodies with disease activity in seronegative rheumatoid arthritis patients. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 19(9), 823-6.
Karimifar, Mansoor, et al. "The association of immunoglobulin A, immunoglobulin G and anti-cyclic citrullinated peptide antibodies with disease activity in seronegative rheumatoid arthritis patients." Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 19,9 (2014): 823-6.
Karimifar M, Moussavi H, Babaei M, Akbari M. The association of immunoglobulin A, immunoglobulin G and anti-cyclic citrullinated peptide antibodies with disease activity in seronegative rheumatoid arthritis patients. J Res Med Sci. 2014 Sep;19(9):823-6. PMID: 25535495; PMCID: PMC4268189.
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J Res Med Sci. 2014 Sep;19(9):823-6.

The association of immunoglobulin A, immunoglobulin G and anti-cyclic citrullinated peptide antibodies with disease activity in seronegative rheumatoid arthritis patients.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Mansoor Karimifar, Hamidreza Moussavi, Mehran Babaei, Mojtaba Akbari

Affiliations

  1. Department of Rheumatology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
  2. Department of Rheumatology, Noor and Aliasghar Hospital, Isfahan, Iran.
  3. Department of Internal Medicine, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
  4. Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 25535495 PMCID: PMC4268189

Abstract

BACKGROUND: Rheumatoid arthritis (RA) is a common autoimmune disease that is associated with progressive disability, systemic complications, and early death. The present study was aimed to investigate the level of immunoglobulin G (IgG) and IgA isotypes and anti-cyclic citrullinated peptide (CCP) antibody and to assess their association with disease severity based on disease activity score (DAS-28) in patients with IgM rheumatoid factor (IgM-RF) negative RA.

MATERIALS AND METHODS: In this cross-sectional study, 62 RA patients with IgM-RF negative were assessed. Radiographs were obtained for all RA patients. The RF (IgG, and IgA) and anti-CCP were measured by using the enzyme-linked immunosorbent assay. Values of cut-off points over 15 UI/mL for IgA IgA-RF, 20 UI/mL for IgG-RF and over 20 units for anti-CCP were considered positive. DAS-28 score was compared in regard to the IgA-RF and IgG-RF and anti-CCP positivity using Mann-Whitney test.

RESULTS: DAS-28 score in IgA-RF positive was significantly higher than IgA-RF negative (mean score, 6.03 ± 0.33 vs. 5.44 ± 0.76 respectively, P = 0.035). In IgG-RF positive patients, DAS-28 score was similar to patients with IgG-RF negative (5.64 ± 0.59 vs. 5.46 ± 0.78 respectively, P = 0.396). Furthermore, in patients with anti-CCP positive DAS-28 score was significantly higher than patients with anti-CCP negative (5.72 ± 0.61 vs. 5.38 ± 0.79 respectively, P = 0.049).

CONCLUSION: Findings indicated that there was a significant association between the amounts of IgA and anti-CCP with severity of disease in RF negative RA patients while there was no significant association between the amounts of IgG and severity of RA disease.

Keywords: Disease activity score-28; immunoglobulin A; immunoglobulin G; rheumatoid factor; seronegative rheumatoid arthritis

References

  1. Ann Rheum Dis. 2002 Jun;61(6):505-10 - PubMed
  2. Arthritis Rheum. 2000 Aug;43(8):1831-5 - PubMed
  3. Am J Med. 2007 Nov;120(11):936-9 - PubMed
  4. Pathophysiology. 2005 Oct;12(3):153-65 - PubMed
  5. Arthritis Res Ther. 2004;6(4):R303-8 - PubMed
  6. Arthritis Rheum. 2004 Jul;50(7):2305-8 - PubMed
  7. Ryumachi. 1995 Jun;35(3):530-7 - PubMed
  8. Ann Rheum Dis. 1987 Jan;46(1):65-71 - PubMed
  9. Arthritis Rheum. 2000 Jan;43(1):155-63 - PubMed
  10. Scand J Rheumatol. 1998;27(4):252-6 - PubMed
  11. J Rheumatol. 2003 Apr;30(4):825-8 - PubMed
  12. Ann Intern Med. 2007 Jun 5;146(11):797-808 - PubMed
  13. Scand J Rheumatol Suppl. 1988;75:233-7 - PubMed
  14. Lancet. 2012 Dec 15;380(9859):2095-128 - PubMed
  15. Adv Biomed Res. 2012;1:30 - PubMed
  16. Ann Rheum Dis. 1992 Jul;51(7):863-8 - PubMed
  17. J Rheumatol. 1997 Jun;24(6):1037-44 - PubMed
  18. Semin Arthritis Rheum. 2006 Dec;36(3):182-8 - PubMed
  19. Ann Rheum Dis. 2008 Feb;67(2):212-7 - PubMed
  20. Arthritis Rheum. 1988 Mar;31(3):315-24 - PubMed
  21. Rheumatol Int. 2008 Aug;28(10 ):965-70 - PubMed
  22. Arch Intern Med. 1992 Dec;152(12):2417-20 - PubMed
  23. Arthritis Rheum. 2003 Oct;48(10):2741-9 - PubMed
  24. N Engl J Med. 2011 Dec 8;365(23):2205-19 - PubMed
  25. Br Med J. 1975 Jul 26;3(5977):203-4 - PubMed
  26. Rheumatology (Oxford). 2006 Apr;45(4):379-85 - PubMed
  27. Clin Dev Immunol. 2005 Sep;12(3):197-202 - PubMed

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