Display options
Cite
Zhou T, Wang F, Meng X, et al. Outcome of endoscopic transsphenoidal surgery in combination with somatostatin analogues in patients with growth hormone producing pituitary adenoma. J Korean Neurosurg Soc. 2014;56(5):405-9doi: 10.3340/jkns.2014.56.5.405.
Zhou, T., Wang, F., Meng, X., Ba, J., Wei, S., & Xu, B. (2014). Outcome of endoscopic transsphenoidal surgery in combination with somatostatin analogues in patients with growth hormone producing pituitary adenoma. Journal of Korean Neurosurgical Society, 56(5), 405-9. https://doi.org/10.3340/jkns.2014.56.5.405
Zhou, Tao, et al. "Outcome of endoscopic transsphenoidal surgery in combination with somatostatin analogues in patients with growth hormone producing pituitary adenoma." Journal of Korean Neurosurgical Society vol. 56,5 (2014): 405-9. doi: https://doi.org/10.3340/jkns.2014.56.5.405
Zhou T, Wang F, Meng X, Ba J, Wei S, Xu B. Outcome of endoscopic transsphenoidal surgery in combination with somatostatin analogues in patients with growth hormone producing pituitary adenoma. J Korean Neurosurg Soc. 2014 Nov;56(5):405-9. doi: 10.3340/jkns.2014.56.5.405. Epub 2014 Nov 30. PMID: 25535518; PMCID: PMC4272999.
Copy Download .nbib Format: NLM
Share it on

J Korean Neurosurg Soc. 2014 Nov;56(5):405-9. doi: 10.3340/jkns.2014.56.5.405. Epub 2014 Nov 30.

Outcome of endoscopic transsphenoidal surgery in combination with somatostatin analogues in patients with growth hormone producing pituitary adenoma.

Journal of Korean Neurosurgical Society

Tao Zhou, Fuyu Wang, Xianghui Meng, Jianmin Ba, Shaobo Wei, Bainan Xu

Affiliations

  1. Department of Neurosurgery, General Hospital of People's Liberation Army, Beijing, China.
  2. Department of Endocrinology, General Hospital of People's Liberation Army, Beijing, China.

PMID: 25535518 PMCID: PMC4272999 DOI: 10.3340/jkns.2014.56.5.405

Abstract

OBJECTIVE: To determine the efficacy of endoscopic surgery in combination with long-acting somatostatin analogues (SSAs) in treating patients with growth hormone (GH)-secreting pituitary tumor.

METHODS: We performed retrospective analysis of 133 patients with GH producing pituitary adenoma who underwent pure endoscopic transsphenoidal surgery in our center from January 2007 to July 2012. Patients were followed up for a range of 3-48 months. The radiological remission, biochemical remission and complication were evaluated.

RESULTS: A total of 110 (82.7%) patients achieved radiological complete resection, 11 (8.2%) subtotal resection, and 12 (9.0%) partial resection. Eighty-eight (66.2%) patients showed nadir GH level less than 1 ng/mL after oral glucose administration. No mortality or severe disability was observed during follow up. Preoperative long-acting SSA successfully improved left ventricle ejection fraction (LVEF) and blood glucose in three patients who subsequently underwent success operation. Long-acting SSA (20 mg every 30 days) achieved biochemical remission in 19 out 23 (82.6%) patients who showed persistent high GH level after surgery.

CONCLUSION: Endoscopic transsphenoidal surgery can biochemically cure the majority of GH producing pituitary adenoma. Post-operative use of SSA can improve biochemical remission.

Keywords: Endoscopic transsphenoidal surgery; GH producing pituitary adenoma; Somatostatin analogue

References

  1. Clin Endocrinol (Oxf). 1994 Jul;41(1):95-102 - PubMed
  2. World Neurosurg. 2013 Jan;79(1):99-109 - PubMed
  3. Endocr Pract. 2011 Jul-Aug;17 Suppl 4:1-44 - PubMed
  4. PLoS One. 2013 Apr 25;8(4):e61523 - PubMed
  5. J Clin Endocrinol Metab. 2007 May;92 (5):1743-7 - PubMed
  6. QJM. 1999 Dec;92(12):741-5 - PubMed
  7. J Clin Endocrinol Metab. 2009 May;94(5):1509-17 - PubMed
  8. J Clin Endocrinol Metab. 2011 Sep;96(9):2732-40 - PubMed
  9. Endocr J. 2010;57(12):1035-44 - PubMed
  10. Neurosurg Focus. 2010 Oct;29(4):E6 - PubMed
  11. Acta Neurochir (Wien). 2005 May;147(5):485-93; discussion 493 - PubMed
  12. J Endocrinol Invest. 2006 Dec;29(11):1017-20 - PubMed
  13. Neurosurgery. 2009 Jul;65(1):63-70; discussion 70-1 - PubMed
  14. Neurosurgery. 2006 Feb;58(1 Suppl):ONS44-51; discussion ONS44-51 - PubMed
  15. Eur J Endocrinol. 2008 Aug;159(2):89-95 - PubMed
  16. J Clin Endocrinol Metab. 2003 Oct;88(10):4709-19 - PubMed
  17. Eur J Endocrinol. 2005 Mar;152(3):379-87 - PubMed

Publication Types