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Liberg B, Klauser P, Harding IH, et al. Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances. Front Psychiatry. 2014;5:176doi: 10.3389/fpsyt.2014.00176.
Liberg, B., Klauser, P., Harding, I. H., Adler, M., Rahm, C., Lundberg, J., Masterman, T., Wachtler, C., Jonsson, T., Kristoffersen-Wiberg, M., Pantelis, C., & Wahlund, B. (2014). Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances. Frontiers in psychiatry, 5176. https://doi.org/10.3389/fpsyt.2014.00176
Liberg, Benny, et al. "Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances." Frontiers in psychiatry vol. 5 (2014): 176. doi: https://doi.org/10.3389/fpsyt.2014.00176
Liberg B, Klauser P, Harding IH, Adler M, Rahm C, Lundberg J, Masterman T, Wachtler C, Jonsson T, Kristoffersen-Wiberg M, Pantelis C, Wahlund B. Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances. Front Psychiatry. 2014 Dec 04;5:176. doi: 10.3389/fpsyt.2014.00176. eCollection 2014. PMID: 25538633; PMCID: PMC4255491.
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Front Psychiatry. 2014 Dec 04;5:176. doi: 10.3389/fpsyt.2014.00176. eCollection 2014.

Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances.

Frontiers in psychiatry

Benny Liberg, Paul Klauser, Ian H Harding, Mats Adler, Christoffer Rahm, Johan Lundberg, Thomas Masterman, Caroline Wachtler, Tomas Jonsson, Maria Kristoffersen-Wiberg, Christos Pantelis, Björn Wahlund

Affiliations

  1. Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia ; Section of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet , Stockholm , Sweden ; Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Medical Imaging and Technology, Karolinska Institutet , Stockholm , Sweden.
  2. Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia ; Monash Clinical and Imaging Neuroscience, School of Psychology and Psychiatry, Monash University , Clayton, VIC , Australia.
  3. Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia ; School of Psychological Sciences, Monash University , Melbourne, VIC , Australia.
  4. Section of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet , Stockholm , Sweden.
  5. Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia ; Department of Medicine Huddinge, Karolinska Institutet , Stockholm , Sweden.
  6. Primary Care Research Unit, Department of General Practice, The University of Melbourne , Melbourne, VIC , Australia ; Centre for Family Medicine (CeFAM), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet , Stockholm , Sweden.
  7. Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Medical Imaging and Technology, Karolinska Institutet , Stockholm , Sweden ; Department of Medical Physics, Karolinska University Hospital Huddinge , Stockholm , Sweden.
  8. Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Medical Imaging and Technology, Karolinska Institutet , Stockholm , Sweden ; Department of Radiology, Karolinska University Hospital , Stockholm , Sweden.
  9. Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia.
  10. Department of Energy and Engineering, Swedish University of Agricultural Sciences , Uppsala , Sweden.

PMID: 25538633 PMCID: PMC4255491 DOI: 10.3389/fpsyt.2014.00176

Abstract

Psychomotor disturbances are a classic feature of major depressive disorders. These can manifest as lack of facial expressions and decreased speech production, reduced body posture and mobility, and slowed voluntary movement. The neural correlates of psychomotor disturbances in depression are poorly understood but it has been suggested that outputs from the cingulate motor area (CMA) to striatal motor regions, including the putamen, could be involved. We used functional and structural magnetic resonance imaging to conduct a region-of-interest analysis to test the hypotheses that neural activation patterns related to motor production and gray matter volumes in the CMA would be different between depressed subjects displaying psychomotor disturbances (n = 13) and matched healthy controls (n = 13). In addition, we conducted a psychophysiological interaction analysis to assess the functional coupling related to self-paced finger-tapping between the caudal CMA and the posterior putamen in patients compared to controls. We found a cluster of increased neural activation, adjacent to a cluster of decreased gray matter volume in the caudal CMA in patients compared to controls. The functional coupling between the left caudal CMA and the left putamen during finger-tapping task performance was additionally decreased in patients compared to controls. In addition, the strength of the functional coupling between the left caudal CMA and the left putamen was negatively correlated with the severity of psychomotor disturbances in the patient group. In conclusion, we found converging evidence for involvement of the caudal CMA and putamen in the generation of psychomotor disturbances in depression.

Keywords: bipolar disorder; cingulate cortex; cingulate motor area; major depression; psychomotor disturbances; putamen; striatum

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