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Mardanian F, Aboutorabi R, Jefride Y, et al. Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis. Adv Biomed Res. 2014;3:226doi: 10.4103/2277-9175.145706.
Mardanian, F., Aboutorabi, R., Jefride, Y., & Amini, G. (2014). Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis. Advanced biomedical research, 3226. https://doi.org/10.4103/2277-9175.145706
Mardanian, Farahnaz, et al. "Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis." Advanced biomedical research vol. 3 (2014): 226. doi: https://doi.org/10.4103/2277-9175.145706
Mardanian F, Aboutorabi R, Jefride Y, Amini G. Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis. Adv Biomed Res. 2014 Nov 29;3:226. doi: 10.4103/2277-9175.145706. eCollection 2014. PMID: 25538912; PMCID: PMC4260278.
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Adv Biomed Res. 2014 Nov 29;3:226. doi: 10.4103/2277-9175.145706. eCollection 2014.

Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis.

Advanced biomedical research

Farahnaz Mardanian, Roshanak Aboutorabi, Yalda Jefride, Guilda Amini

Affiliations

  1. Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.
  2. Department of Anatomical Sciences, Head of Infertility Laboratory, Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
  3. Department of Genetics, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 25538912 PMCID: PMC4260278 DOI: 10.4103/2277-9175.145706

Abstract

BACKGROUND: The purpose of this study was to determine whether variability in gene encoding for promoter of tumor necrosis factor participates to women differences in susceptibility to endometriosis.

MATERIALS AND METHODS: The study involved 130 women; 65 endometriotic and 65 healthy control women. The blood samples were genotyped for -850 T/C and -863 C/A polymorphisms in TNF alpha gene promoter. Chi-square, odd ratio, and confidence interval 95% were used to evaluate genotypes and allele frequency differences between two groups.

RESULTS: No significant differences in genotypes distribution of -850 T/C (P = 0.32) and 863 C/A (P = 0.34) polymorphisms were obtained between two groups.

CONCLUSION: According to this study, these two polymorphisms have no risk or protective factor to develop endometriosis.

Keywords: Endometriosis; polymorphism; tumor necrosis factor

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