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Soares JM, Marques P, Magalhães R, et al. Brain structure across the lifespan: the influence of stress and mood. Front Aging Neurosci. 2014;6:330doi: 10.3389/fnagi.2014.00330.
Soares, J. M., Marques, P., Magalhães, R., Santos, N. C., & Sousa, N. (2014). Brain structure across the lifespan: the influence of stress and mood. Frontiers in aging neuroscience, 6330. https://doi.org/10.3389/fnagi.2014.00330
Soares, José M, et al. "Brain structure across the lifespan: the influence of stress and mood." Frontiers in aging neuroscience vol. 6 (2014): 330. doi: https://doi.org/10.3389/fnagi.2014.00330
Soares JM, Marques P, Magalhães R, Santos NC, Sousa N. Brain structure across the lifespan: the influence of stress and mood. Front Aging Neurosci. 2014 Nov 24;6:330. doi: 10.3389/fnagi.2014.00330. eCollection 2014. PMID: 25505411; PMCID: PMC4241814.
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Front Aging Neurosci. 2014 Nov 24;6:330. doi: 10.3389/fnagi.2014.00330. eCollection 2014.

Brain structure across the lifespan: the influence of stress and mood.

Frontiers in aging neuroscience

José M Soares, Paulo Marques, Ricardo Magalhães, Nadine C Santos, Nuno Sousa

Affiliations

  1. Life and Health Sciences Research Institute, School of Health Sciences, University of Minho Braga, Portugal ; ICVS/3B's - PT Government Associate Laboratory Braga/Guimarães, Portugal ; Clinical Academic Center - Braga Braga, Portugal.

PMID: 25505411 PMCID: PMC4241814 DOI: 10.3389/fnagi.2014.00330

Abstract

Normal brain aging is an inevitable and heterogeneous process characterized by a selective pattern of structural changes. Such heterogeneity arises as a consequence of cumulative effects over the lifespan, including stress and mood effects, which drive different micro- and macro-structural alterations in the brain. Investigating these differences in healthy age-related changes is a major challenge for the comprehension of the cognitive status. Herein we addressed the impact of normal aging, stress, mood, and their interplay in the brain gray and white matter (WM) structure. We showed the critical impact of age in the WM volume and how stress and mood influence brain volumetry across the lifespan. Moreover, we found a more profound effect of the interaction of aging/stress/mood on structures located in the left hemisphere. These findings help to clarify some divergent results associated with the aging decline and to enlighten the association between abnormal volumetric alterations and several states that may lead to psychiatric disorders.

Keywords: aging; gray matter; mood; stress; volumetry; white matter

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