Display options
Cite
Leneveu-Jenvrin C, Connil N, Bouffartigues E, et al. Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas. Front Microbiol. 2014;5:631doi: 10.3389/fmicb.2014.00631.
Leneveu-Jenvrin, C., Connil, N., Bouffartigues, E., Papadopoulos, V., Feuilloley, M. G., & Chevalier, S. (2014). Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas. Frontiers in microbiology, 5631. https://doi.org/10.3389/fmicb.2014.00631
Leneveu-Jenvrin, Charlène, et al. "Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas." Frontiers in microbiology vol. 5 (2014): 631. doi: https://doi.org/10.3389/fmicb.2014.00631
Leneveu-Jenvrin C, Connil N, Bouffartigues E, Papadopoulos V, Feuilloley MG, Chevalier S. Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas. Front Microbiol. 2014 Nov 19;5:631. doi: 10.3389/fmicb.2014.00631. eCollection 2014. PMID: 25477872; PMCID: PMC4237140.
Copy Download .nbib Format: NLM
Share it on

Front Microbiol. 2014 Nov 19;5:631. doi: 10.3389/fmicb.2014.00631. eCollection 2014.

Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas.

Frontiers in microbiology

Charlène Leneveu-Jenvrin, Nathalie Connil, Emeline Bouffartigues, Vassilios Papadopoulos, Marc G J Feuilloley, Sylvie Chevalier

Affiliations

  1. Laboratory of Microbiology Signals and Microenvironment EA 4312, University of Rouen Evreux, France.
  2. Department of Medicine, Research Institute of the McGill University Health Centre, McGill University Montreal, QC, Canada.

PMID: 25477872 PMCID: PMC4237140 DOI: 10.3389/fmicb.2014.00631

Abstract

The translocator protein (TSPO), which was previously designated as the peripheral-type benzodiazepine receptor, is a 3.5 billion year-old evolutionarily conserved protein expressed by most Eukarya, Archae and Bacteria, but its organization and functions differ remarkably. By taking advantage of the genomic data available on TSPO, we focused on bacterial TSPO and attempted to define functions of TSPO in Pseudomonas via in silico approaches. A tspo ortholog has been identified in several fluorescent Pseudomonas. This protein presents putative binding motifs for cholesterol and PK 11195, which is a specific drug ligand of mitochondrial TSPO. While it is a common surface distribution, the sense of insertion and membrane localization differ between α- and γ-proteobacteria. Experimental published data and STRING analysis of common TSPO partners in fluorescent Pseudomonas indicate a potential role of TSPO in the oxidative stress response, iron homeostasis and virulence expression. In these bacteria, TSPO could also take part in signal transduction and in the preservation of membrane integrity.

Keywords: Pseudomonas; TSPO; bacteria; function; structure; translocator protein

References

  1. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5003-8 - PubMed
  2. J Biol Chem. 2011 Aug 5;286(31):27515-27 - PubMed
  3. Science. 1985 Sep 20;229(4719):1281-3 - PubMed
  4. Nat Rev Drug Discov. 2010 Dec;9(12):971-88 - PubMed
  5. Res Microbiol. 2004 Jan-Feb;155(1):39-46 - PubMed
  6. Endocrinology. 2014 Jan;155(1):89-97 - PubMed
  7. Proc Natl Acad Sci U S A. 1984 Feb;81(3):753-6 - PubMed
  8. Steroids. 2003 Sep;68(7-8):569-85 - PubMed
  9. Nucleic Acids Res. 2011 Jan;39(Database issue):D596-600 - PubMed
  10. Photosynth Res. 2004;80(1-3):353-60 - PubMed
  11. J Neuroimmune Pharmacol. 2013 Mar;8(1):51-7 - PubMed
  12. Cell Metab. 2010 Oct 6;12(4):373-85 - PubMed
  13. PLoS One. 2009 Jun 30;4(6):e6096 - PubMed
  14. Biochemistry. 2009 Jul 28;48(29):6909-20 - PubMed
  15. Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1374-8 - PubMed
  16. Gastroenterology. 2001 Apr;120(5):1212-26 - PubMed
  17. Biochem Biophys Res Commun. 2003 Nov 28;311(4):847-52 - PubMed
  18. Biochim Biophys Acta. 2008 Nov;1780(11):1304-17 - PubMed
  19. Science. 2005 Jul 29;309(5735):774-7 - PubMed
  20. J Biol Chem. 1990 Mar 5;265(7):3772-9 - PubMed
  21. Eur J Pharmacol. 2000 Oct 13;406(2):171-80 - PubMed
  22. J Nucl Med. 2014 Mar;55(3):466-72 - PubMed
  23. Annu Rev Microbiol. 2011;65:261-86 - PubMed
  24. Nat Rev Microbiol. 2008 Feb;6(2):111-20 - PubMed
  25. J Lipid Res. 2011 Dec;52(12):2111-35 - PubMed
  26. Mol Microbiol. 2001 Mar;39(5):1116-23 - PubMed
  27. Eur J Pharmacol. 1991 Dec 12;208(4):307-12 - PubMed
  28. Appl Microbiol Biotechnol. 2010 May;86(6):1637-45 - PubMed
  29. J Cell Biol. 2007 Dec 31;179(7):1355-63 - PubMed
  30. Cell Biol Toxicol. 2007 Nov;23(6):385-400 - PubMed
  31. Biol Rev Camb Philos Soc. 2013 Nov;88(4):955-87 - PubMed
  32. Biochem Pharmacol. 1996 Dec 24;52(12):1805-14 - PubMed
  33. Plant Cell. 2002;14 Suppl:S15-45 - PubMed
  34. Proc Natl Acad Sci U S A. 1997 May 13;94(10 ):5101-6 - PubMed
  35. Chem Biol. 1994 Sep;1(1):11-23 - PubMed
  36. J Burn Care Res. 2010 Jan-Feb;31(1):1-12 - PubMed
  37. Plant Cell. 2011 Feb;23(2):785-805 - PubMed
  38. Curr Mol Med. 2012 May;12(4):369-86 - PubMed
  39. Trends Pharmacol Sci. 2006 Aug;27(8):402-9 - PubMed
  40. Life Sci. 1983 Apr 18;32(16):1849-56 - PubMed
  41. Science. 1997 Aug 1;277(5326):653-9 - PubMed
  42. Endocrinology. 1998 Dec;139(12 ):4991-7 - PubMed
  43. Mol Microbiol. 2002 Sep;45(6):1599-611 - PubMed
  44. J Biochem. 1995 Apr;117(4):875-80 - PubMed
  45. Plant J. 2009 Oct;60(2):242-56 - PubMed
  46. J Biol Chem. 1995 Sep 8;270(36):21167-75 - PubMed
  47. Proc Natl Acad Sci U S A. 1977 Sep;74(9):3805-9 - PubMed
  48. Trends Microbiol. 2006 Feb;14(2):55-8 - PubMed
  49. Nature. 2004 Apr 8;428(6983):617-24 - PubMed
  50. Orig Life Evol Biosph. 1998 Oct;28(4-6):539-53 - PubMed
  51. FEMS Microbiol Lett. 2014 Apr;353(1):1-10 - PubMed
  52. Annu Rev Biochem. 2000;69:183-215 - PubMed
  53. J Bioenerg Biomembr. 1992 Feb;24(1):63-9 - PubMed
  54. Mol Pharmacol. 1989 Jan;35(1):164-72 - PubMed
  55. Mol Microbiol. 2003 Jan;47(2):471-81 - PubMed
  56. Plant J. 2007 Sep;51(6):1004-18 - PubMed
  57. Biochimie. 2014 May;100:61-77 - PubMed
  58. Int J Biochem Cell Biol. 2013 Jul;45(7):1212-6 - PubMed
  59. BMC Microbiol. 2013 Apr 12;13:81 - PubMed
  60. J Nat Prod. 2011 May 27;74(5):1281-3 - PubMed
  61. Mol Plant Microbe Interact. 2014 Jun;27(6):537-45 - PubMed
  62. Science. 1996 Oct 11;274(5285):255-9 - PubMed
  63. J Bacteriol. 2001 Aug;183(15):4571-9 - PubMed
  64. Mol Cell Endocrinol. 2013 May 22;371(1-2):34-46 - PubMed
  65. Curr Pharm Des. 2007;13(23 ):2385-405 - PubMed
  66. Biochemistry. 2009 Jun 2;48(21):4652-61 - PubMed
  67. Biol Direct. 2013 Aug 15;8:20 - PubMed
  68. Mol Endocrinol. 2005 Mar;19(3):588-94 - PubMed
  69. Clinics (Sao Paulo). 2012 Jul;67(7):827-30 - PubMed
  70. Steroids. 1997 Jan;62(1):21-8 - PubMed
  71. Mol Cell Endocrinol. 2010 Oct 7;327(1-2):1-12 - PubMed
  72. Biochim Biophys Acta. 1998 Mar 30;1391(2):223-32 - PubMed
  73. Biochemistry. 2003 Apr 22;42(15):4506-19 - PubMed
  74. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7217-22 - PubMed
  75. Front Physiol. 2013 Feb 28;4:31 - PubMed
  76. Cancer Res. 2005 Dec 1;65(23 ):11051-60 - PubMed
  77. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10420-5 - PubMed
  78. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2419-23 - PubMed
  79. J Mol Graph Model. 2013 Sep;45:173-9 - PubMed
  80. Am J Respir Crit Care Med. 2014 Apr 1;189(7):812-24 - PubMed
  81. J Biol Chem. 2013 May 17;288(20):14200-11 - PubMed
  82. Mol Plant Microbe Interact. 2012 Mar;25(3):363-71 - PubMed
  83. J Biol Chem. 1997 Dec 19;272(51):32129-35 - PubMed
  84. Endocrinology. 2013 Jun;154(6):2156-65 - PubMed
  85. ISME J. 2011 Dec;5(12):1957-68 - PubMed
  86. Infect Immun. 2011 Mar;79(3):1176-86 - PubMed
  87. J Biol Chem. 2000 Feb 25;275(8):5657-67 - PubMed
  88. Science. 2009 Jul 24;325(5939):490-3 - PubMed
  89. Int Microbiol. 2000 Mar;3(1):3-8 - PubMed
  90. J Biol Chem. 1999 Jul 23;274(30):21234-43 - PubMed
  91. BMC Plant Biol. 2011 Jun 20;11:108 - PubMed
  92. Biochim Biophys Acta. 1998 Aug 10;1366(1-2):53-67 - PubMed
  93. Front Plant Sci. 2014 Jun 25;5:308 - PubMed
  94. Genome Biol Evol. 2009 Sep 10;1:364-81 - PubMed
  95. Mol Cell Endocrinol. 1992 Sep;87(1-3):R1-6 - PubMed
  96. Appl Environ Microbiol. 2000 Dec;66(12):5353-9 - PubMed
  97. PLoS One. 2013;8(2):e55085 - PubMed
  98. Biochemistry. 2013 May 28;52(21):3609-11 - PubMed
  99. Biochemistry. 2009 Jul 7;48(26):6041-3 - PubMed
  100. Annu Rev Plant Biol. 2005;56:165-85 - PubMed
  101. Biochem Biophys Res Commun. 2001 Jun 8;284(2):536-41 - PubMed
  102. Amino Acids. 2009 Sep;37(3):443-58 - PubMed
  103. Mol Cell Endocrinol. 2007 Feb;265-266:59-64 - PubMed
  104. Dalton Trans. 2013 Mar 7;42(9):3107-15 - PubMed
  105. J Biol Chem. 2014 Oct 3;289(40):27444-54 - PubMed
  106. J Biol Chem. 2006 Oct 20;281(42):31729-35 - PubMed
  107. Glia. 2011 Feb;59(2):219-30 - PubMed
  108. BMC Bioinformatics. 2011 Jan 26;12:35 - PubMed
  109. Trends Plant Sci. 2010 Sep;15(9):488-98 - PubMed
  110. Genome Biol. 2001;2(6):REVIEWS1018 - PubMed
  111. J Enzyme Inhib Med Chem. 2013 Feb;28(1):1-10 - PubMed
  112. Trends Biochem Sci. 1999 Mar;24(3):88-93 - PubMed
  113. Biochem Pharmacol. 1996 May 17;51(10 ):1283-92 - PubMed
  114. Plant Signal Behav. 2009 Nov;4(11):1087-90 - PubMed
  115. J Bacteriol. 2001 Nov;183(21):6355-64 - PubMed
  116. Appl Environ Microbiol. 2011 Dec;77(24):8676-86 - PubMed
  117. Arch Biochem Biophys. 2012 Sep 15;525(2):145-60 - PubMed
  118. Science. 2014 Mar 21;343 (6177):1363-6 - PubMed
  119. Plant Cell Physiol. 2004 Jun;45(6):723-33 - PubMed
  120. Mol Cell Endocrinol. 2013 May 22;371(1-2):26-33 - PubMed
  121. J Biol Chem. 1990 Sep 5;265(25):15015-22 - PubMed
  122. Nature. 1971 Apr 16;230(5294):473-4 - PubMed
  123. Biochemistry. 2011 Jun 14;50(23):5236-48 - PubMed
  124. Mol Endocrinol. 2012 Nov;26(11):1868-82 - PubMed
  125. Life Sci. 1992;50(3):203-12 - PubMed
  126. Microbiology. 2013 Oct;159(Pt 10):2049-57 - PubMed
  127. Nucleic Acids Res. 2007 Jan;35(Database issue):D358-62 - PubMed
  128. Endocrinology. 2014 Jan;155(1):15-20 - PubMed

Publication Types