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Bissonnette L, Bergeron MG. Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies. J Pers Med. 2012;2(2):50-70doi: 10.3390/jpm2020050.
Bissonnette, L., & Bergeron, M. G. (2012). Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies. Journal of personalized medicine, 2(2), 50-70. https://doi.org/10.3390/jpm2020050
Bissonnette, Luc, and Bergeron, Michel G. "Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies." Journal of personalized medicine vol. 2,2 (2012): 50-70. doi: https://doi.org/10.3390/jpm2020050
Bissonnette L, Bergeron MG. Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies. J Pers Med. 2012 May 02;2(2):50-70. doi: 10.3390/jpm2020050. PMID: 25562799; PMCID: PMC4251365.
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J Pers Med. 2012 May 02;2(2):50-70. doi: 10.3390/jpm2020050.

Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies.

Journal of personalized medicine

Luc Bissonnette, Michel G Bergeron

Affiliations

  1. Département de microbiologie-infectiologie et d'immunologie, Faculté de médecine, Université Laval, Centre de recherche du CHUQ, 2705 Laurier blvd., Québec City (Québec), G1V 4G2, Canada. [email protected].
  2. Département de microbiologie-infectiologie et d'immunologie, Faculté de médecine, Université Laval, Centre de recherche du CHUQ, 2705 Laurier blvd., Québec City (Québec), G1V 4G2, Canada. [email protected].

PMID: 25562799 PMCID: PMC4251365 DOI: 10.3390/jpm2020050

Abstract

Infectious disease management essentially consists in identifying the microbial cause(s) of an infection, initiating if necessary antimicrobial therapy against microbes, and controlling host reactions to infection. In clinical microbiology, the turnaround time of the diagnostic cycle (>24 hours) often leads to unnecessary suffering and deaths; approaches to relieve this burden include rapid diagnostic procedures and more efficient transmission or interpretation of molecular microbiology results. Although rapid nucleic acid-based diagnostic testing has demonstrated that it can impact on the transmission of hospital-acquired infections, we believe that such life-saving procedures should be performed closer to the patient, in dedicated 24/7 laboratories of healthcare institutions, or ideally at point of care. While personalized medicine generally aims at interrogating the genomic information of a patient, drug metabolism polymorphisms, for example, to guide drug choice and dosage, personalized medicine concepts are applicable in infectious diseases for the (rapid) identification of a disease-causing microbe and determination of its antimicrobial resistance profile, to guide an appropriate antimicrobial treatment for the proper management of the patient. The implementation of point-of-care testing for infectious diseases will require acceptance by medical authorities, new technological and communication platforms, as well as reimbursement practices such that time- and life-saving procedures become available to the largest number of patients.

References

  1. Expert Rev Mol Diagn. 2011 May;11(4):367-81 - PubMed
  2. Curr Opin Infect Dis. 2010 Aug;23(4):311-9 - PubMed
  3. PLoS One. 2010 Feb 17;5(2):e9215 - PubMed
  4. Expert Rev Mol Diagn. 2006 May;6(3):433-50 - PubMed
  5. Transl Res. 2009 Dec;154(6):277-87 - PubMed
  6. Clin Invest Med. 2008 Oct 01;31(5):E265-71 - PubMed
  7. Lab Chip. 2007 Sep;7(9):1094-110 - PubMed
  8. Crit Care Med. 2008 Jan;36(1):296-327 - PubMed
  9. Anal Bioanal Chem. 2009 Jun;394(3):731-42 - PubMed
  10. Int J Med Microbiol. 2010 Aug;300(6):411-3 - PubMed
  11. J Clin Microbiol. 2008 Jun;46(6):2074-7 - PubMed
  12. Clin Chem Lab Med. 2007;45(6):766-73 - PubMed
  13. Diagn Microbiol Infect Dis. 2007 Dec;59(4):401-6 - PubMed
  14. J Clin Microbiol. 2008 Jan;46(1):97-102 - PubMed
  15. J Intensive Care Med. 2010 Sep;25(5):259-70 - PubMed
  16. BMC Med. 2011 Sep 22;9:107 - PubMed
  17. J Clin Microbiol. 2009 Sep;47(9):3021-3 - PubMed
  18. Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S14-9 - PubMed
  19. Curr Issues Mol Biol. 2007 Jan;9(1):21-39 - PubMed
  20. Clin Infect Dis. 2011 May;52 Suppl 4:S326-30 - PubMed
  21. Crit Care. 2010;14(5):R186 - PubMed
  22. Tuberculosis (Edinb). 2011 Nov;91(6):524-32 - PubMed
  23. Clin Infect Dis. 2007 Dec 15;45(12):1568-75 - PubMed
  24. Lab Chip. 2012 Feb 7;12(3):464-73 - PubMed
  25. BMC Infect Dis. 2009 Aug 24;9:137 - PubMed
  26. Clin Lab Med. 2007 Dec;27(4):893-908, viii - PubMed
  27. Integr Biol (Camb). 2009 Oct;1(10):574-86 - PubMed
  28. Curr Opin Infect Dis. 2011 Feb;24 Suppl 1:S1-10 - PubMed
  29. Clin Chem Lab Med. 2008;46(7):888-908 - PubMed
  30. Pediatr Infect Dis J. 2008 Nov;27(11):1009-12 - PubMed
  31. Anal Chim Acta. 2009 Apr 13;638(2):115-25 - PubMed
  32. Curr Opin Microbiol. 2011 Oct;14(5):564-9 - PubMed
  33. Biomed Microdevices. 2012 Feb;14(1):45-53 - PubMed
  34. Clin Infect Dis. 2010 Nov 1;51(9):1074-80 - PubMed
  35. Anal Bioanal Chem. 2012 Jan;402(2):741-8 - PubMed
  36. Annu Rev Genomics Hum Genet. 2011;12:217-44 - PubMed
  37. Lab Chip. 2010 Feb 7;10(3):363-71 - PubMed
  38. Trends Microbiol. 2010 Aug;18(8):357-64 - PubMed
  39. Acad Emerg Med. 2010 Oct;17(10):1072-9 - PubMed
  40. Clin Lab Med. 2009 Sep;29(3):463-78 - PubMed
  41. J Clin Virol. 2008 Dec;43(4):401-6 - PubMed
  42. Clin Infect Dis. 2011 May;52 Suppl 4:S305-11 - PubMed
  43. Expert Rev Mol Diagn. 2011 Apr;11(3):287-98 - PubMed
  44. Eur J Clin Pharmacol. 2007 Jul;63(7):633-9 - PubMed
  45. Expert Rev Mol Diagn. 2008 Nov;8(6):679-88 - PubMed
  46. Analyst. 2010 Jul;135(7):1499-518 - PubMed
  47. Expert Rev Mol Diagn. 2010 Oct;10(7):937-46 - PubMed
  48. Clin Pharmacol Ther. 2010 Dec;88(6):754-6 - PubMed
  49. Medicine (Baltimore). 2011 Nov;90(6):390-5 - PubMed
  50. Biotechnol Adv. 2006 May-Jun;24(3):243-84 - PubMed
  51. Clin Microbiol Infect. 2010 Aug;16(8):1044-53 - PubMed
  52. N Engl J Med. 2011 Sep 15;365(11):1033-41 - PubMed
  53. Health Policy. 2007 Feb;80(2):340-57 - PubMed
  54. Am J Pharmacogenomics. 2005;5(6):345-55 - PubMed
  55. J Clin Microbiol. 2011 Jun;49(6):2279-82 - PubMed
  56. Curr Opin Infect Dis. 2011 Feb;24 Suppl 1:S11-20 - PubMed
  57. Int J Microbiol. 2011;2011:861514 - PubMed
  58. Lab Chip. 2010 Apr 7;10(7):909-17 - PubMed
  59. Curr Opin Drug Discov Devel. 2010 Mar;13(2):226-34 - PubMed
  60. Cell Cycle. 2008 Aug;7(15):2278-85 - PubMed
  61. Trends Biotechnol. 2011 May;29(5):240-50 - PubMed
  62. J Clin Microbiol. 2010 Apr;48(4):1305-9 - PubMed
  63. Lab Chip. 2010 Jul 21;10(14):1758-73 - PubMed
  64. Lab Chip. 2007 May;7(5):565-73 - PubMed
  65. Anal Bioanal Chem. 2008 Jan;390(1):89-111 - PubMed
  66. JAMA. 2010 Dec 15;304(23):2579-80 - PubMed
  67. Clin Infect Dis. 2011 May;52 Suppl 4:S373-83 - PubMed
  68. Lab Chip. 2011 Nov 21;11(22):3752-65 - PubMed
  69. Arch Microbiol. 2011 Dec;193(12):883-91 - PubMed
  70. J Antimicrob Chemother. 2011 Apr;66 Suppl 2:ii33-40 - PubMed
  71. J Am Chem Soc. 2011 Jun 15;133(23):9129-35 - PubMed
  72. Clin Microbiol Rev. 2009 Oct;22(4):611-33 - PubMed
  73. Rev Sci Instrum. 2009 Oct;80(10 ):101101 - PubMed
  74. Int J Antimicrob Agents. 2010 Dec;36 Suppl 2:S6-16 - PubMed
  75. Clin Lab Med. 2009 Sep;29(3):555-60 - PubMed
  76. Anal Bioanal Chem. 2009 Mar;393(5):1499-504 - PubMed
  77. Pharmacoeconomics. 2010;28(7):567-75 - PubMed
  78. Antimicrob Agents Chemother. 2005 May;49(5):1733-8 - PubMed
  79. Future Microbiol. 2009 Feb;4(1):45-64 - PubMed
  80. PLoS One. 2011;6(7):e22403 - PubMed
  81. Clin Microbiol Infect. 2010 Aug;16(8):1054-61 - PubMed
  82. Lab Chip. 2011 Sep 7;11(17):2813-8 - PubMed
  83. Expert Rev Mol Diagn. 2010 May;10(4):399-415 - PubMed
  84. Pharmacotherapy. 2011 Sep;31(9):912-21 - PubMed
  85. Br J Anaesth. 2003 Apr;90(4):425-7 - PubMed
  86. Anal Chem. 2008 Sep 1;80(17):6472-9 - PubMed
  87. Expert Rev Mol Diagn. 2011 Jun;11(5):505-19 - PubMed
  88. Anal Chim Acta. 2011 Feb 14;687(1):12-27 - PubMed
  89. Arch Pathol Lab Med. 2011 Jan;135(1):83-91 - PubMed
  90. J Hosp Infect. 2007 Jan;65(1):24-8 - PubMed
  91. Lancet Infect Dis. 2008 Nov;8(11):710-9 - PubMed
  92. J Appl Microbiol. 2010 Dec;109(6):1853-67 - PubMed
  93. Clin Infect Dis. 2011 May;52 Suppl 4:S384-95 - PubMed
  94. Clin Infect Dis. 2004 Nov 15;39(10):1425-30 - PubMed
  95. Biotechnol Annu Rev. 2008;14:411-22 - PubMed
  96. Clin Infect Dis. 2012 Mar 1;54(5):684-91 - PubMed
  97. Expert Opin Med Diagn. 2009 Jan;3(1):1-4 - PubMed
  98. Diagn Microbiol Infect Dis. 2011 Nov;71(3):224-9 - PubMed
  99. Expert Rev Med Devices. 2009 Nov;6(6):641-51 - PubMed
  100. Expert Rev Mol Diagn. 2010 Oct;10(7):875-82 - PubMed
  101. Future Microbiol. 2010 Nov;5(11):1733-54 - PubMed
  102. Biomed Microdevices. 2011 Feb;13(1):19-27 - PubMed
  103. Crit Care Med. 2006 Jun;34(6):1589-96 - PubMed
  104. Clin Microbiol Infect. 2010 Nov;16(11):1604-13 - PubMed
  105. N Engl J Med. 2012 Feb 9;366(6):489-91 - PubMed
  106. Annu Rev Biomed Eng. 2006;8:601-28 - PubMed
  107. Anal Chem. 2011 Feb 1;83(3):982-8 - PubMed
  108. Infect Control Hosp Epidemiol. 2008 Nov;29(11):1077-9 - PubMed
  109. J Hosp Med. 2011 Sep;6(7):405-10 - PubMed
  110. N Engl J Med. 2000 Jul 20;343(3):175-9 - PubMed

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