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Bala S, Sharma N, Kajal A, et al. Mannich bases: an important pharmacophore in present scenario. Int J Med Chem. 2014;2014:191072doi: 10.1155/2014/191072.
Bala, S., Sharma, N., Kajal, A., Kamboj, S., & Saini, V. (2014). Mannich bases: an important pharmacophore in present scenario. International journal of medicinal chemistry, 2014191072. https://doi.org/10.1155/2014/191072
Bala, Suman, et al. "Mannich bases: an important pharmacophore in present scenario." International journal of medicinal chemistry vol. 2014 (2014): 191072. doi: https://doi.org/10.1155/2014/191072
Bala S, Sharma N, Kajal A, Kamboj S, Saini V. Mannich bases: an important pharmacophore in present scenario. Int J Med Chem. 2014;2014:191072. doi: 10.1155/2014/191072. Epub 2014 Nov 12. PMID: 25478226; PMCID: PMC4244926.
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Int J Med Chem. 2014;2014:191072. doi: 10.1155/2014/191072. Epub 2014 Nov 12.

Mannich bases: an important pharmacophore in present scenario.

International journal of medicinal chemistry

Suman Bala, Neha Sharma, Anu Kajal, Sunil Kamboj, Vipin Saini

Affiliations

  1. M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.

PMID: 25478226 PMCID: PMC4244926 DOI: 10.1155/2014/191072

Abstract

Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to α, β-unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group.

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