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Taverna J, Nair A, Yun S, et al. A rare presentation of in situ mantle cell lymphoma and follicular lymphoma: a case report and review of the literature. Case Rep Hematol. 2014;2014:145129doi: 10.1155/2014/145129.
Taverna, J., Nair, A., Yun, S., Paulson, S., Schatz, J. H., Persky, D., Fuchs, D., & Puvvada, S. (2014). A rare presentation of in situ mantle cell lymphoma and follicular lymphoma: a case report and review of the literature. Case reports in hematology, 2014145129. https://doi.org/10.1155/2014/145129
Taverna, Josephine, et al. "A rare presentation of in situ mantle cell lymphoma and follicular lymphoma: a case report and review of the literature." Case reports in hematology vol. 2014 (2014): 145129. doi: https://doi.org/10.1155/2014/145129
Taverna J, Nair A, Yun S, Paulson S, Schatz JH, Persky D, Fuchs D, Puvvada S. A rare presentation of in situ mantle cell lymphoma and follicular lymphoma: a case report and review of the literature. Case Rep Hematol. 2014;2014:145129. doi: 10.1155/2014/145129. Epub 2014 Nov 16. PMID: 25478252; PMCID: PMC4249607.
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Case Rep Hematol. 2014;2014:145129. doi: 10.1155/2014/145129. Epub 2014 Nov 16.

A rare presentation of in situ mantle cell lymphoma and follicular lymphoma: a case report and review of the literature.

Case reports in hematology

Josephine Taverna, Anju Nair, Seongseok Yun, Spencer Paulson, Jonathan H Schatz, Daniel Persky, Deborah Fuchs, Soham Puvvada

Affiliations

  1. Division of Hematology and Oncology, Department of Medicine, University of Arizona Cancer Center, University of Arizona, USA.
  2. Department of Medicine, University of Arizona, USA.
  3. Department of Pathology, University of Arizona, USA.

PMID: 25478252 PMCID: PMC4249607 DOI: 10.1155/2014/145129

Abstract

A 65-year-old gentleman presented with left groin swelling over the course of two months. Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions. An excisional lymph node biopsy was performed. Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells. These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL) with in situ mantle cell lymphoma (MCLIS). FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown. This case illustrates the diagnostic and therapeutic challenges of composite lymphomas. This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.

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