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Narayan J, Ghildiyal A, Goyal M, et al. Cold pressor response in high landers versus low landers. J Clin Diagn Res. 2014;8(10):BC08-11doi: 10.7860/JCDR/2014/10768.5009.
Narayan, J., Ghildiyal, A., Goyal, M., Verma, D., Singh, S., & Tiwari, S. (2014). Cold pressor response in high landers versus low landers. Journal of clinical and diagnostic research : JCDR, 8(10), BC08-11. https://doi.org/10.7860/JCDR/2014/10768.5009
Narayan, Jagdish, et al. "Cold pressor response in high landers versus low landers." Journal of clinical and diagnostic research : JCDR vol. 8,10 (2014): BC08-11. doi: https://doi.org/10.7860/JCDR/2014/10768.5009
Narayan J, Ghildiyal A, Goyal M, Verma D, Singh S, Tiwari S. Cold pressor response in high landers versus low landers. J Clin Diagn Res. 2014 Oct;8(10):BC08-11. doi: 10.7860/JCDR/2014/10768.5009. Epub 2014 Oct 20. PMID: 25478333; PMCID: PMC4253151.
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J Clin Diagn Res. 2014 Oct;8(10):BC08-11. doi: 10.7860/JCDR/2014/10768.5009. Epub 2014 Oct 20.

Cold pressor response in high landers versus low landers.

Journal of clinical and diagnostic research : JCDR

Jagdish Narayan, Archana Ghildiyal, Manish Goyal, Dileep Verma, Shraddha Singh, Sunita Tiwari

Affiliations

  1. Assistant Professor, Department of Physiology, King George's Medical University , Lucknow, Uttar Pradesh, India .
  2. Associate Professor, Department of Physiology, King George's Medical University , Lucknow, Uttar Pradesh, India .
  3. Assistant Professor, Department of Physiology, All India Institute of Medical Sciences , Bhubaneswar, Odisha, India .
  4. Professor, Department of Physiology, King George's Medical University , Lucknow, Uttar Pradesh, India .

PMID: 25478333 PMCID: PMC4253151 DOI: 10.7860/JCDR/2014/10768.5009

Abstract

BACKGROUND: Native high landers face two main environmental challenges i.e. hypobaric hypoxia and low ambient temperatures. Both factors contribute to increased sympathetic stimulation and increased blood pressure. Despite these challenges, subjects living at high altitude have lower systolic and diastolic pressures as compared to subjects living in plains. Present study investigated cold pressor test (CPT) which is a potential predictor of future hypertension in high landers and low landers Materials and Methods: Vascular reactivity in terms of changes in systolic and diastolic blood pressure and heart rate in response to cold pressor test has been compared in high lander (n=45) and low lander (n=46) population.

RESULTS: Systolic and diastolic blood pressure changes and heart rate changes with cold pressor test are lower in high landers as compared to low landers. Females in both the groups in general exhibited greater cold pressor response than males.

CONCLUSION: Hypo-reactive cold pressor test is due to higher parasympathetic tone and lower sympathetic tone. Decreased cold pressor response in high landers reflects another adaptive modulation of sympatho-vagal activity that enables them to stay in hypobaric atmosphere and lower temperatures without undue autonomic stress.

Keywords: Altitude; Autonomic; CPT; Hypertension; Parasympathetic; Sympathetic

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