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Mishel P, Bychkov D, Kallio-Kokko H, et al. Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells. Genome Announc. 2014;2(6)doi: 10.1128/genomeA.01349-14.
Mishel, P., Bychkov, D., Kallio-Kokko, H., Valkonen, M., Kantele, A., Mattila, P., Almusa, H., Jalovaara, P., & Kainov, D. (2014). Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells. Genome announcements, 2(6), . https://doi.org/10.1128/genomeA.01349-14
Mishel, Polina, et al. "Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells." Genome announcements vol. 2,6 (2014). doi: https://doi.org/10.1128/genomeA.01349-14
Mishel P, Bychkov D, Kallio-Kokko H, Valkonen M, Kantele A, Mattila P, Almusa H, Jalovaara P, Kainov D. Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells. Genome Announc. 2014 Dec 24;2(6). doi: 10.1128/genomeA.01349-14. PMID: 25540354; PMCID: PMC4276832.
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Genome Announc. 2014 Dec 24;2(6). doi: 10.1128/genomeA.01349-14.

Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells.

Genome announcements

Polina Mishel, Dmitrii Bychkov, Hannimari Kallio-Kokko, Miia Valkonen, Anu Kantele, Pirkko Mattila, Henrikki Almusa, Petri Jalovaara, Denis Kainov

Affiliations

  1. The Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
  2. Helsinki University Hospital Laboratory, HUSLAB, Helsinki, Finland.
  3. Helsinki University Central Hospital, HUCS, Helsinki, Finland.
  4. The Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland [email protected].

PMID: 25540354 PMCID: PMC4276832 DOI: 10.1128/genomeA.01349-14

Abstract

Here, we sequenced the genome of the influenza A/Finland/741 M/2014(H1N1) virus and found that the virus accumulated oseltamivir resistance mutation H275Y in its neuraminidase during propagation in cell culture. This indicates that propagation in cell culture modifies virus genomes. The instability of influenza genomes should be taken into consideration during drug-sensitivity studies.

Copyright © 2014 Mishel et al.

References

  1. Genome Announc. 2014 Jan 16;2(1):null - PubMed
  2. J Med Virol. 2015 Jan;87(1):45-56 - PubMed
  3. Genome Announc. 2014 Oct 02;2(5):null - PubMed

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