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Hidalgo JV, Bronsert P, Orlowska-Volk M, et al. Histological Analysis of γδ T Lymphocytes Infiltrating Human Triple-Negative Breast Carcinomas. Front Immunol. 2014;5:632doi: 10.3389/fimmu.2014.00632.
Hidalgo, J. V., Bronsert, P., Orlowska-Volk, M., Díaz, L. B., Stickeler, E., Werner, M., Schmitt-Graeff, A., Kayser, G., Malkovsky, M., & Fisch, P. (2014). Histological Analysis of γδ T Lymphocytes Infiltrating Human Triple-Negative Breast Carcinomas. Frontiers in immunology, 5632. https://doi.org/10.3389/fimmu.2014.00632
Hidalgo, Jose Villacorta, et al. "Histological Analysis of γδ T Lymphocytes Infiltrating Human Triple-Negative Breast Carcinomas." Frontiers in immunology vol. 5 (2014): 632. doi: https://doi.org/10.3389/fimmu.2014.00632
Hidalgo JV, Bronsert P, Orlowska-Volk M, Díaz LB, Stickeler E, Werner M, Schmitt-Graeff A, Kayser G, Malkovsky M, Fisch P. Histological Analysis of γδ T Lymphocytes Infiltrating Human Triple-Negative Breast Carcinomas. Front Immunol. 2014 Dec 10;5:632. doi: 10.3389/fimmu.2014.00632. eCollection 2014. PMID: 25540645; PMCID: PMC4261817.
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Front Immunol. 2014 Dec 10;5:632. doi: 10.3389/fimmu.2014.00632. eCollection 2014.

Histological Analysis of γδ T Lymphocytes Infiltrating Human Triple-Negative Breast Carcinomas.

Frontiers in immunology

Jose Villacorta Hidalgo, Peter Bronsert, Marzenna Orlowska-Volk, Liliana B Díaz, Elmar Stickeler, Martin Werner, Annette Schmitt-Graeff, Gian Kayser, Miroslav Malkovsky, Paul Fisch

Affiliations

  1. Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany ; Faculty of Biology, University of Freiburg , Freiburg im Breisgau , Germany ; University Hospital "José de San Martin", University of Buenos Aires , Buenos Aires , Argentina.
  2. Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany ; Comprehensive Cancer Center , Freiburg im Breisgau , Germany.
  3. Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany.
  4. University Hospital "José de San Martin", University of Buenos Aires , Buenos Aires , Argentina.
  5. Comprehensive Cancer Center , Freiburg im Breisgau , Germany ; Department of Obstetrics and Gynecology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany.
  6. Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA.

PMID: 25540645 PMCID: PMC4261817 DOI: 10.3389/fimmu.2014.00632

Abstract

Breast cancer is the leading cause of cancer death in women and the second most common cancer worldwide after lung cancer. The remarkable heterogeneity of breast cancers influences numerous diagnostic, therapeutic, and prognostic factors. Triple-negative breast carcinomas (TNBCs) lack expression of HER2 and the estrogen and progesterone receptors and often contain lymphocytic infiltrates. Most of TNBCs are invasive ductal carcinomas (IDCs) with poor prognosis, whereas prognostically more favorable subtypes such as medullary breast carcinomas (MBCs) are somewhat less frequent. Infiltrating T-cells have been associated with an improved clinical outcome in TNBCs. The prognostic role of γδ T-cells within CD3(+) tumor-infiltrating T lymphocytes remains unclear. We analyzed 26 TNBCs, 14 IDCs, and 12 MBCs, using immunohistochemistry for the quantity and patterns of γδ T-cell infiltrates within the tumor microenvironment. In both types of TNBCs, we found higher numbers of γδ T-cells in comparison with normal breast tissues and fibroadenomas. The numbers of infiltrating γδ T-cells were higher in MBCs than in IDCs. γδ T-cells in MBCs were frequently located in direct contact with tumor cells, within the tumor and at its invasive border. In contrast, most γδ T-cells in IDCs were found in clusters within the tumor stroma. These findings could be associated with the fact that the patient's prognosis in MBCs is better than that in IDCs. Further studies to characterize these γδ T-cells at the molecular and functional level are in progress.

Keywords: breast cancer; histology; paraffin material; triple-negative breast cancer; γδ T-cells

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