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Tabur S, Oguz E, Eren MA, et al. Serum prolidase activity is associated with non-diabetic metabolic syndrome. Diabetol Metab Syndr. 2014;6(1):142doi: 10.1186/1758-5996-6-142.
Tabur, S., Oguz, E., Eren, M. A., Korkmaz, H., Savas, E., Aksoy, N., & Sabuncu, T. (2014). Serum prolidase activity is associated with non-diabetic metabolic syndrome. Diabetology & metabolic syndrome, 6(1), 142. https://doi.org/10.1186/1758-5996-6-142
Tabur, Suzan, et al. "Serum prolidase activity is associated with non-diabetic metabolic syndrome." Diabetology & metabolic syndrome vol. 6,1 (2014): 142. doi: https://doi.org/10.1186/1758-5996-6-142
Tabur S, Oguz E, Eren MA, Korkmaz H, Savas E, Aksoy N, Sabuncu T. Serum prolidase activity is associated with non-diabetic metabolic syndrome. Diabetol Metab Syndr. 2014 Dec 17;6(1):142. doi: 10.1186/1758-5996-6-142. eCollection 2014. PMID: 25540672; PMCID: PMC4276100.
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Diabetol Metab Syndr. 2014 Dec 17;6(1):142. doi: 10.1186/1758-5996-6-142. eCollection 2014.

Serum prolidase activity is associated with non-diabetic metabolic syndrome.

Diabetology & metabolic syndrome

Suzan Tabur, Elif Oguz, Mehmet Ali Eren, Hakan Korkmaz, Esen Savas, Nurten Aksoy, Tevfik Sabuncu

Affiliations

  1. Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
  2. Faculty of Medicine, Department of Medical Pharmacology, Harran University, 63300 Sanliurfa, Turkey.
  3. Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Harran University, 63300 Sanliurfa, Turkey.
  4. Faculty of Medicine, Department of Internal Medicine, Gaziantep University, 27100 Sahinbey, Gaziantep Turkey.
  5. Faculty of Medicine, Department of Clinical Biochemistry, Harran University, 63300 Sanliurfa, Turkey.

PMID: 25540672 PMCID: PMC4276100 DOI: 10.1186/1758-5996-6-142

Abstract

OBJECTIVE: The aim of this study was to determine the role of serum prolidase activity and the possible association with oxidative stress parameters in non-diabetic metabolic syndrome.

METHODS: 30 obese patients without metabolic syndrome (MetS), 34 non-diabetic obese patients with MetS, and 23 volunteer control subjects were enrolled in the study. Fasting plasma glucose (FPG), plasma glucose following 75 g glucose administration, high-density lipoprotein- cholesterol (HDL-C), high-density lipoprotein- cholesterol (LDL-C), total cholesterol, triglyceride (TG), total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and prolidase activities of all subjects were analyzed.

RESULTS: Prolidase levels was significantly higher in MetS group compared to both obese and control groups (p < 0.001 and p < 0.05 respectively). Prolidase was also higher in the obese group than in the control group (p < 0.05). Prolidase was negatively correlated with TAS and HDL-C (r = -0,362, p < 0.001; r = -0.320, p < 0.01, respectively) and positively correlated with BMI, weight, waist-c, SBP, DBP, TG, TC, LDL-C.

CONCLUSION: Prolidase activity may have a role in the pathogenesis of metabolic syndrome.

Keywords: Metabolic syndrome; Non-diabetic; Obesity; Prolidase

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