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Russell ZE, Chen EX, Amsden JJ, et al. Two-dimensional aperture coding for magnetic sector mass spectrometry. J Am Soc Mass Spectrom. 2014;26(2):248-56doi: 10.1007/s13361-014-1051-4.
Russell, Z. E., Chen, E. X., Amsden, J. J., Wolter, S. D., Danell, R. M., Parker, C. B., Stoner, B. R., Gehm, M. E., Brady, D. J., & Glass, J. T. (2015). Two-dimensional aperture coding for magnetic sector mass spectrometry. Journal of the American Society for Mass Spectrometry, 26(2), 248-56. https://doi.org/10.1007/s13361-014-1051-4
Russell, Zachary E, et al. "Two-dimensional aperture coding for magnetic sector mass spectrometry." Journal of the American Society for Mass Spectrometry vol. 26,2 (2015): 248-56. doi: https://doi.org/10.1007/s13361-014-1051-4
Russell ZE, Chen EX, Amsden JJ, Wolter SD, Danell RM, Parker CB, Stoner BR, Gehm ME, Brady DJ, Glass JT. Two-dimensional aperture coding for magnetic sector mass spectrometry. J Am Soc Mass Spectrom. 2015 Feb;26(2):248-56. doi: 10.1007/s13361-014-1051-4. Epub 2014 Dec 16. PMID: 25510933.
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J Am Soc Mass Spectrom. 2015 Feb;26(2):248-56. doi: 10.1007/s13361-014-1051-4. Epub 2014 Dec 16.

Two-dimensional aperture coding for magnetic sector mass spectrometry.

Journal of the American Society for Mass Spectrometry

Zachary E Russell, Evan X Chen, Jason J Amsden, Scott D Wolter, Ryan M Danell, Charles B Parker, Brian R Stoner, Michael E Gehm, David J Brady, Jeffrey T Glass

Affiliations

  1. Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.

PMID: 25510933 DOI: 10.1007/s13361-014-1051-4

Abstract

In mass spectrometer design, there has been a historic belief that there exists a fundamental trade-off between instrument size, throughput, and resolution. When miniaturizing a traditional system, performance loss in either resolution or throughput would be expected. However, in optical spectroscopy, both one-dimensional (1D) and two-dimensional (2D) aperture coding have been used for many years to break a similar trade-off. To provide a viable path to miniaturization for harsh environment field applications, we are investigating similar concepts in sector mass spectrometry. Recently, we demonstrated the viability of 1D aperture coding and here we provide a first investigation of 2D coding. In coded optical spectroscopy, 2D coding is preferred because of increased measurement diversity for improved conditioning and robustness of the result. To investigate its viability in mass spectrometry, analytes of argon, acetone, and ethanol were detected using a custom 90-degree magnetic sector mass spectrometer incorporating 2D coded apertures. We developed a mathematical forward model and reconstruction algorithm to successfully reconstruct the mass spectra from the 2D spatially coded ion positions. This 2D coding enabled a 3.5× throughput increase with minimal decrease in resolution. Several challenges were overcome in the mass spectrometer design to enable this coding, including the need for large uniform ion flux, a wide gap magnetic sector that maintains field uniformity, and a high resolution 2D detection system for ion imaging. Furthermore, micro-fabricated 2D coded apertures incorporating support structures were developed to provide a viable design that allowed ion transmission through the open elements of the code.

References

  1. Opt Express. 2013 Oct 21;21(21):25480-91 - PubMed
  2. Appl Spectrosc. 2006 Jun;60(6):663-71 - PubMed
  3. Appl Opt. 2007 Aug 1;46(22):4932-42 - PubMed
  4. J Am Soc Mass Spectrom. 2015 Sep;26(9):1633-40 - PubMed
  5. Appl Opt. 1993 Dec 1;32(34):7095-105 - PubMed
  6. Appl Opt. 2008 Apr 1;47(10):B44-51 - PubMed
  7. Annu Rev Anal Chem (Palo Alto Calif). 2009;2:187-214 - PubMed
  8. J Mass Spectrom. 2000 Jun;35(6):659-71 - PubMed
  9. Opt Express. 2007 Oct 17;15(21):14013-27 - PubMed
  10. Appl Opt. 2006 May 1;45(13):2965-74 - PubMed

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