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Kerr J, Quinti I, Eibl M, et al. Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe. Front Immunol. 2014;5:629doi: 10.3389/fimmu.2014.00629.
Kerr, J., Quinti, I., Eibl, M., Chapel, H., Späth, P. J., Sewell, W. A., Salama, A., van Schaik, I. N., Kuijpers, T. W., & Peter, H. H. (2014). Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe. Frontiers in immunology, 5629. https://doi.org/10.3389/fimmu.2014.00629
Kerr, Jacqueline, et al. "Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe." Frontiers in immunology vol. 5 (2014): 629. doi: https://doi.org/10.3389/fimmu.2014.00629
Kerr J, Quinti I, Eibl M, Chapel H, Späth PJ, Sewell WA, Salama A, van Schaik IN, Kuijpers TW, Peter HH. Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe. Front Immunol. 2014 Dec 12;5:629. doi: 10.3389/fimmu.2014.00629. eCollection 2014. PMID: 25566244; PMCID: PMC4263903.
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Front Immunol. 2014 Dec 12;5:629. doi: 10.3389/fimmu.2014.00629. eCollection 2014.

Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe.

Frontiers in immunology

Jacqueline Kerr, Isabella Quinti, Martha Eibl, Helen Chapel, Peter J Späth, W A Carrock Sewell, Abdulgabar Salama, Ivo N van Schaik, Taco W Kuijpers, Hans-Hartmut Peter

Affiliations

  1. Section Poly- and Monoclonal Antibodies, Paul Ehrlich Institut , Langen , Germany.
  2. Department of Molecular Medicine, Sapienza University of Rome , Rome , Italy.
  3. Immunologische Tagesklinik , Vienna , Austria.
  4. Nuffield Department of Medicine, University of Oxford , Oxford , UK.
  5. Institute of Pharmacology, University of Bern , Bern , Switzerland.
  6. Hull York Medical School, University of Lincoln , Lincoln , UK.
  7. Zentrum für Transfusionsmedizin u. Zelltherapie, Charité , Berlin , Germany.
  8. Department of Neurology, Academic Medical Center (AMC), University of Amsterdam , Amsterdam , Netherlands.
  9. Department of Pediatric Hematology, Immunology and Infectious disease, Academic Medical Center (AMC), University of Amsterdam , Amsterdam , Netherlands.
  10. Centrum für chronische Immunodeficienz (CCI), University Medical Centre, University of Freiburg , Freiburg im Breisgau , Germany.

PMID: 25566244 PMCID: PMC4263903 DOI: 10.3389/fimmu.2014.00629

Abstract

The consumption of immunoglobulins (Ig) is increasing due to better recognition of antibody deficiencies, an aging population, and new indications. This review aims to examine the various dosing regimens and research developments in the established and in some of the relevant off-label indications in Europe. The background to the current regulatory settings in Europe is provided as a backdrop for the latest developments in primary and secondary immunodeficiencies and in immunomodulatory indications. In these heterogeneous areas, clinical trials encompassing different routes of administration, varying intervals, and infusion rates are paving the way toward more individualized therapy regimens. In primary antibody deficiencies, adjustments in dosing and intervals will depend on the clinical presentation, effective IgG trough levels and IgG metabolism. Ideally, individual pharmacokinetic profiles in conjunction with the clinical phenotype could lead to highly tailored treatment. In practice, incremental dosage increases are necessary to titrate the optimal dose for more severely ill patients. Higher intravenous doses in these patients also have beneficial immunomodulatory effects beyond mere IgG replacement. Better understanding of the pharmacokinetics of Ig therapy is leading to a move away from simplistic "per kg" dosing. Defective antibody production is common in many secondary immunodeficiencies irrespective of whether the causative factor was lymphoid malignancies (established indications), certain autoimmune disorders, immunosuppressive agents, or biologics. This antibody failure, as shown by test immunization, may be amenable to treatment with replacement Ig therapy. In certain immunomodulatory settings [e.g., idiopathic thrombocytopenic purpura (ITP)], selection of patients for Ig therapy may be enhanced by relevant biomarkers in order to exclude non-responders and thus obtain higher response rates. In this review, the developments in dosing of therapeutic immunoglobulins have been limited to high and some medium priority indications such as ITP, Kawasaki' disease, Guillain-Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy, myasthenia gravis, multifocal motor neuropathy, fetal alloimmune thrombocytopenia, fetal hemolytic anemia, and dermatological diseases.

Keywords: IVIG; SCIG; dosing; immunomodulation; replacement therapy

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