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Takatsu K. Revisiting the identification and cDNA cloning of T cell-replacing factor/interleukin-5. Front Immunol. 2014;5:639doi: 10.3389/fimmu.2014.00639.
Takatsu, K. (2014). Revisiting the identification and cDNA cloning of T cell-replacing factor/interleukin-5. Frontiers in immunology, 5639. https://doi.org/10.3389/fimmu.2014.00639
Takatsu, Kiyoshi. "Revisiting the identification and cDNA cloning of T cell-replacing factor/interleukin-5." Frontiers in immunology vol. 5 (2014): 639. doi: https://doi.org/10.3389/fimmu.2014.00639
Takatsu K. Revisiting the identification and cDNA cloning of T cell-replacing factor/interleukin-5. Front Immunol. 2014 Dec 23;5:639. doi: 10.3389/fimmu.2014.00639. eCollection 2014. PMID: 25566252; PMCID: PMC4274987.
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Front Immunol. 2014 Dec 23;5:639. doi: 10.3389/fimmu.2014.00639. eCollection 2014.

Revisiting the identification and cDNA cloning of T cell-replacing factor/interleukin-5.

Frontiers in immunology

Kiyoshi Takatsu

Affiliations

  1. Toyama Prefectural Institute for Pharmaceutical Research , Imizu City, Toyama , Japan ; Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Sciences , Toyama City, Toyama , Japan.

PMID: 25566252 PMCID: PMC4274987 DOI: 10.3389/fimmu.2014.00639

Abstract

This is a perspective based on the paper "Cloning of complementary DNA encoding T cell-replacing factor and identity with B cell growth factor II," by Kinashi et al. (1). We have been interested in understanding the molecular basis of T-B cell cooperation for antibody formation. Although many investigators had described a number of different soluble factors that appeared to have biological relevance to T-B cell interactions, molecular basis of such active substances remained unknown for a long period of time. In this perspective, I will briefly summarize the history of the initial discovery of T cell-replacing factor/B cell growth factor II that appeared to be involved in B cell growth and differentiation, and outline the discovery and characterization of interleukin-5. Studies of interleukin-5 have provided strong evidence that a single cytokine exerts a variety of activities on diverse target cells.

Keywords: B cell differentiation factor; B cell growth factor; IL-5; TRF; eosinophil differentiation factor

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