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Lee YM, Kim SM, Park SJ, et al. Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis. Infect Chemother. 2014;46(4):248-52doi: 10.3947/ic.2014.46.4.248.
Lee, Y. M., Kim, S. M., Park, S. J., Lee, S. O., Choi, S. H., Kim, Y. S., Woo, J. H., & Kim, S. H. (2014). Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis. Infection & chemotherapy, 46(4), 248-52. https://doi.org/10.3947/ic.2014.46.4.248
Lee, Yu-Mi, et al. "Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis." Infection & chemotherapy vol. 46,4 (2014): 248-52. doi: https://doi.org/10.3947/ic.2014.46.4.248
Lee YM, Kim SM, Park SJ, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH. Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis. Infect Chemother. 2014 Dec;46(4):248-52. doi: 10.3947/ic.2014.46.4.248. Epub 2014 Dec 29. PMID: 25566404; PMCID: PMC4285001.
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Infect Chemother. 2014 Dec;46(4):248-52. doi: 10.3947/ic.2014.46.4.248. Epub 2014 Dec 29.

Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis.

Infection & chemotherapy

Yu-Mi Lee, Sun-Mi Kim, Su Jin Park, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim

Affiliations

  1. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ; Department of Infectious Diseases, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
  2. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

PMID: 25566404 PMCID: PMC4285001 DOI: 10.3947/ic.2014.46.4.248

Abstract

Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×10(5) PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×10(5) PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.

Keywords: Interferon-gamma release assay; Miliary; Tuberculosis

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