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Bernabei R, Martone AM, Ortolani E, et al. Screening, diagnosis and treatment of osteoporosis: a brief review. Clin Cases Miner Bone Metab. 2014;11(3):201-7
Bernabei, R., Martone, A. M., Ortolani, E., Landi, F., & Marzetti, E. (2014). Screening, diagnosis and treatment of osteoporosis: a brief review. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 11(3), 201-7.
Bernabei, Roberto, et al. "Screening, diagnosis and treatment of osteoporosis: a brief review." Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases vol. 11,3 (2014): 201-7.
Bernabei R, Martone AM, Ortolani E, Landi F, Marzetti E. Screening, diagnosis and treatment of osteoporosis: a brief review. Clin Cases Miner Bone Metab. 2014 Sep;11(3):201-7. PMID: 25568654; PMCID: PMC4269144.
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Clin Cases Miner Bone Metab. 2014 Sep;11(3):201-7.

Screening, diagnosis and treatment of osteoporosis: a brief review.

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

Roberto Bernabei, Anna Maria Martone, Elena Ortolani, Francesco Landi, Emanuele Marzetti

Affiliations

  1. Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome, Italy.

PMID: 25568654 PMCID: PMC4269144

Abstract

Osteoporosis is a highly prevalent condition characterized by decreases in bone mass and microarchitectural alterations. Bone fractures, especially of the hip and vertebrae, are the most burdensome complications of osteoporosis, being associated with high risk of disability, institutionalization and mortality. The detection of osteoporosis relies on the quantification of bone mineral density via imaging techniques such as dual-energy X-ray absorptiometry. However, therapeutic decision-making should be based on a comprehensive fracture risk assessment, which may be obtained through validated algorithms. Once the decision of treating has been taken, non-pharmacological strategies should be implemented together with the prescription of anti-osteoporotic agents. Numerous drugs are currently available to treat osteoporosis and the choice of a specific compound should be guided by efficacy and safety considerations. The present review provides a concise synopsis of the current evidence in the management of osteoporosis, from screening to drug prescription. Novel anti-osteoporotic agents are also briefly presented.

Keywords: bisphosphonates; denosumab; strontium ranelate; teriparatide; vitamin D

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