Vet Res Forum. 2014;5(1):35-41.
The effects of short term intravenous infusion of a soybean based lipid emulsion on some blood constituents in sheep: A preliminary study.
Veterinary research forum : an international quarterly journal
Hamid Akbari, Bahram Dalir-Naghadeh
Affiliations
Affiliations
- Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
PMID: 25568690
PMCID: PMC4279665
Abstract
To evaluate the effect of intravenous infusion of a soybean based lipid emulsion (Lipovenoes 10%) on some blood constituents in sheep, a replicated 2 × 2 Latin square design experiment was conducted in four clinically healthy ewes. Lipid emulsion (LE group) or normal saline (NS group) was infused intravenously at a rate of 0.025 mL kg(-1) per min for 6 hr and the concentrations of blood triglyceride, glucose, insulin, calcium, magnesium, phosphorous, sodium and potassium were measured before (baseline) and then at timepoints 2, 4, 6, 12 and 24 hr after infusion. Compared to the baseline values and/or NS infusion, LE infusion resulted in a significant increase in the concentrations of triglyceride (p < 0.001), glucose (p < 0.01), calcium (p < 0.05), phosphorous (p < 0.01) and a significant decrease in insulin (p < 0.001) and magnesium (p < 0.05) concentrations. Compared to the baseline value, the homeostasis model of insulin resistance (HOMA-IR) index increased (p < 0.001) at timepoints 2 and 4 hr and abruptly decreased at timepoint six hr (p < 0.01) following LE infusion. In LE group, HOMA-IR values were significantly (p < 0.001) higher than those for NS group at timepoints 2 and 4 hr after infusion. Neither treatment nor time influenced serum sodium and potassium concentrations (p > 0.05). In conclusion, intravenous infusion of Lipovenoes temporarily influenced some blood constituents. Increased triglyceride concentrations were associated with an increase in HOMA-IR values indicating a state of insulin resistance. No remarkable adverse effect was observed following LE infusion and lipid based emulsions can be safely used in ruminants not suffering from extensive lipid mobilization.
Keywords: Blood constituents; Insulin resistance; Lipid emulsion; Sheep
References
- Domest Anim Endocrinol. 2009 Nov;37(4):250-61 - PubMed
- J Vet Emerg Crit Care (San Antonio). 2011 Aug;21(4):309-20 - PubMed
- Scand J Trauma Resusc Emerg Med. 2010 Oct 05;18:51 - PubMed
- J Pediatr Surg. 2011 Apr;46(4):666-73 - PubMed
- Metabolism. 1982 Nov;31(11):1128-36 - PubMed
- Magnes Res. 2004 Jun;17(2):126-36 - PubMed
- Vet Clin North Am Equine Pract. 2009 Apr;25(1):93-108, vii - PubMed
- J Med Toxicol. 2008 Sep;4(3):184-91 - PubMed
- JPEN J Parenter Enteral Nutr. 1988 Jan-Feb;12(1):84-7 - PubMed
- Vet Clin North Am Small Anim Pract. 2012 Mar;42(2):251-62, vi - PubMed
- Vet Clin North Am Food Anim Pract. 2013 Jul;29(2):367-86 - PubMed
- Emerg Med Australas. 2011 Apr;23(2):123-41 - PubMed
- Vet Clin North Am Food Anim Pract. 2013 Jul;29(2):299-322 - PubMed
- Clin Nutr. 1984 Dec;3(4):203-7 - PubMed
- J Dairy Sci. 2008 Sep;91(9):3363-71 - PubMed
- Nutr Clin Pract. 2006 Aug;21(4):342-50 - PubMed
- Clin Sci (Lond). 1989 Feb;76(2):165-70 - PubMed
- Intensive Care Med. 2010 May;36(5):735-49 - PubMed
- Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E723-30 - PubMed
- J Dairy Sci. 2007 Jun;90(6):2735-44 - PubMed
- J Dairy Sci. 2007 Oct;90(10):4635-42 - PubMed
- J Intensive Care Med. 2014 Mar-Apr;29(2):59-70 - PubMed
- Acad Emerg Med. 2009 Sep;16(9):815-24 - PubMed
- Diabetologia. 1996 Sep;39(9):1074-82 - PubMed
- J Dairy Sci. 2012 Feb;95(2):670-82 - PubMed
- J Dairy Sci. 2006 Aug;89(8):2999-3005 - PubMed
- Prog Lipid Res. 1997 Sep;36(2-3):131-51 - PubMed
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