Display options
Cite
Ardila CM, Olarte-Sossa M, Guzmán IC. Association between immunoglobulin G1 against Tannerella forsythia and reduction in the loss of attachment tissue. J Periodontal Implant Sci. 2014;44(6):274-9doi: 10.5051/jpis.2014.44.6.274.
Ardila, C. M., Olarte-Sossa, M., & Guzmán, I. C. (2014). Association between immunoglobulin G1 against Tannerella forsythia and reduction in the loss of attachment tissue. Journal of periodontal & implant science, 44(6), 274-9. https://doi.org/10.5051/jpis.2014.44.6.274
Ardila, Carlos Martín, et al. "Association between immunoglobulin G1 against Tannerella forsythia and reduction in the loss of attachment tissue." Journal of periodontal & implant science vol. 44,6 (2014): 274-9. doi: https://doi.org/10.5051/jpis.2014.44.6.274
Ardila CM, Olarte-Sossa M, Guzmán IC. Association between immunoglobulin G1 against Tannerella forsythia and reduction in the loss of attachment tissue. J Periodontal Implant Sci. 2014 Dec;44(6):274-9. doi: 10.5051/jpis.2014.44.6.274. Epub 2014 Dec 31. PMID: 25568807; PMCID: PMC4284375.
Copy Download .nbib Format: NLM
Share it on

J Periodontal Implant Sci. 2014 Dec;44(6):274-9. doi: 10.5051/jpis.2014.44.6.274. Epub 2014 Dec 31.

Association between immunoglobulin G1 against Tannerella forsythia and reduction in the loss of attachment tissue.

Journal of periodontal & implant science

Carlos Martín Ardila, Mariana Olarte-Sossa, Isabel Cristina Guzmán

Affiliations

  1. Biomedical Stomatology Group, Universidad de Antioquia U de A, Medellín, Colombia.

PMID: 25568807 PMCID: PMC4284375 DOI: 10.5051/jpis.2014.44.6.274

Abstract

PURPOSE: To evaluate whether the levels of immunoglobulin G (IgG) antibody to Tanerella forsythia are associated with periodontal status.

METHODS: Patients with a diagnosis of chronic periodontitis were considered candidates for the study; thus 80 chronic periodontitis patients and 28 healthy persons (control group) were invited to participate in this investigation. The presence of T. forsythia was detected by polymerase chain reaction (PCR) analysis using primers designed to target the respective 16S rRNA gene sequences. Peripheral blood was collected from each subject to identify the IgG1 and IgG2 serum antibodies against T. forsythia. All microbiological and immunological laboratory processes were completed blindly, without awareness of the clinical status of the study patients or of the periodontal sites tested.

RESULTS: The bivariate analysis showed that lower mean levels of clinical attachment level (CAL) and probing depth were found in the presence of the IgG1 antibody titers against whole-cell T. forsythia; however, only the difference in CAL was statistically significant. In the presence of the IgG2 antibody titers against whole-cell T. forsythia, the periodontal parameters evaluated were higher but they did not show statistical differences, except for plaque. The unadjusted linear regression model showed that the IgG1 antibody against whole-cell T. forsythia in periodontitis patients was associated with a lower mean CAL (β=-0.654; 95% confidence interval [CI], -1.27 to -0.28; P<0.05). This statistically significant association remained after adjusting for possible confounders (β=-0.655; 95% CI, -1.28 to -0.29; P<0.05). On the other hand, smoking was a statistically significant risk factor in the model (β=0.704; 95% CI, 0.24 to 1.38; P<0.05).

CONCLUSIONS: Significantly lower mean levels of CAL were shown in the presence of the IgG1 antibody titers against whole-cell T. forsythia in periodontitis patients. Thus, the results of this study suggest that IgG1 antibody to T. forsythia may have been a protective factor from periodontitis in this sample.

Keywords: Chronic periodontitis; Immunoglobulin G; Periodontal disease; Periodontitis

References

  1. J Periodontol. 1998 Feb;69(2):171-7 - PubMed
  2. Oral Microbiol Immunol. 2007 Jun;22(3):152-61 - PubMed
  3. J Clin Microbiol. 1984 Apr;19(4):447-52 - PubMed
  4. J Periodontol. 2012 Feb;83(2):228-34 - PubMed
  5. J Periodontal Res. 2010 Oct;45(5):672-80 - PubMed
  6. J Periodontol. 2012 Dec;83(12):1449-54 - PubMed
  7. Clin Diagn Lab Immunol. 2003 May;10(3):383-7 - PubMed
  8. J Periodontal Res. 2002 Apr;37(2):132-46 - PubMed
  9. J Periodontol. 1997 Aug;68(8):734-8 - PubMed
  10. J Periodontol. 1991 Dec;62(12):781-91 - PubMed
  11. Adv Dent Res. 2014 May;26(1):15-22 - PubMed
  12. J Clin Periodontol. 2000 Nov;27(11):839-45 - PubMed
  13. Oral Dis. 2014 Nov;20(8):803-8 - PubMed
  14. J Periodontol. 2014 Oct;85(10):1450-7 - PubMed
  15. Arch Oral Biol. 2013 Aug;58(8):1007-13 - PubMed
  16. J Periodontol. 2009 Apr;80(4):634-47 - PubMed
  17. Annu Rev Biochem. 2002;71:635-700 - PubMed
  18. Periodontol 2000. 1999 Jun;20:289-340 - PubMed
  19. J Clin Periodontol. 1998 Feb;25(2):134-44 - PubMed
  20. FEMS Microbiol Lett. 2007 Oct;275(2):344-52 - PubMed
  21. Infect Immun. 1992 Jun;60(6):2194-200 - PubMed
  22. J Clin Periodontol. 2010 Aug 1;37(8):685-96 - PubMed
  23. Adv Dent Res. 1988 Nov;2(2):339-45 - PubMed
  24. Oral Microbiol Immunol. 1996 Aug;11(4):266-73 - PubMed
  25. J Clin Periodontol. 1988 Jul;15(6):390-8 - PubMed
  26. Periodontol 2000. 2007;43:14-40 - PubMed
  27. J Periodontal Res. 2003 Oct;38(5):471-6 - PubMed
  28. Science. 1999 Jul 30;285(5428):736-9 - PubMed

Publication Types