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Casini G, Yurashevich M, Vanga R, et al. Are Periventricular Lesions Specific for Multiple Sclerosis?. J Neurol Neurophysiol. 2013;4(2):150doi: 10.4172/2155-9562.1000150.
Casini, G., Yurashevich, M., Vanga, R., Dash, S., Dhib-Jalbut, S., Gerhardstein, B., Inglese, M., Toe, W., & Balashov, K. E. (2013). Are Periventricular Lesions Specific for Multiple Sclerosis?. Journal of neurology & neurophysiology, 4(2), 150. https://doi.org/10.4172/2155-9562.1000150
Casini, Gianna, et al. "Are Periventricular Lesions Specific for Multiple Sclerosis?." Journal of neurology & neurophysiology vol. 4,2 (2013): 150. doi: https://doi.org/10.4172/2155-9562.1000150
Casini G, Yurashevich M, Vanga R, Dash S, Dhib-Jalbut S, Gerhardstein B, Inglese M, Toe W, Balashov KE. Are Periventricular Lesions Specific for Multiple Sclerosis?. J Neurol Neurophysiol. 2013 May 03;4(2):150. doi: 10.4172/2155-9562.1000150. PMID: 25568815; PMCID: PMC4283830.
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J Neurol Neurophysiol. 2013 May 03;4(2):150. doi: 10.4172/2155-9562.1000150.

Are Periventricular Lesions Specific for Multiple Sclerosis?.

Journal of neurology & neurophysiology

Gianna Casini, Mary Yurashevich, Rohini Vanga, Subasini Dash, Suhayl Dhib-Jalbut, Brian Gerhardstein, Matilde Inglese, Win Toe, Konstantin E Balashov

Affiliations

  1. Department of Neurology, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

PMID: 25568815 PMCID: PMC4283830 DOI: 10.4172/2155-9562.1000150

Abstract

BACKGROUND: The presence of periventricular lesions (PVL) on MRI scans is part of the revised McDonald multiple sclerosis (MS) diagnostic criteria. However, PVL can be found in other neurological diseases including stroke and migraine. Migraine is highly prevalent in patients with MS.

OBJECTIVE: To determine if PVL are specific for patients with MS compared to stroke and migraine.

METHODS: We studied patients diagnosed with clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), migraine, and ischemic stroke. The number, location and the volume of PVL were identified on brain MRI scans and analyzed.

RESULTS: The number and volume of PVL adjacent to the body and the posterior horn of the lateral ventricles were significantly increased on fluid-attenuated inversion recovery MRI in RRMS compared to migraine. There were no significant differences in the total number and volume of PVL in ischemic stroke patients compared to the age-matched RRMS patients nor in the number and volume of PVL adjacent to the anterior and temporal horns of the lateral ventricles on FLAIR images in migraine compared to CIS or RRMS.

CONCLUSION: In contrast to PVL adjacent to the body and the posterior horn of the lateral ventricles, PVL adjacent to the anterior and temporal horns of the lateral ventricles may not be specific for CIS/RRMS when compared to migraine, the disease highly prevalent among patients with MS. PVL are not specific for MS when compared to ischemic stroke.

Keywords: MRI; Migraine; Multiple sclerosis; Stroke

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