Glob Adv Health Med. 2014 Nov;3(6):50-5. doi: 10.7453/gahmj.2014.053.
Customized nutritional enhancement for pregnant women appears to lower incidence of certain common maternal and neonatal complications: an observational study.
Global advances in health and medicine
Leslie P Stone, P Michael Stone, Emily A Rydbom, Lucas A Stone, T Elliot Stone, Lindsey E Wilkens, Kathryn Reynolds
Affiliations
Affiliations
- Stone Medical PC, Ashland, Oregon (Dr Stone), United States.
- Stone Medical PC, Ashland, Oregon (Ms E. Rydbom), United States.
- Stone Medical PC, Ashland, Oregon (Mr L.A. Stone), United States.
- Independent statistician consultant (Mr T.E. Stone), United States.
- Stone Medical PC, Ashland, Oregon (Ms L. Wilkens), United States.
- Stone Medical PC, Ashland, Oregon (Ms K. Reynolds), United States.
PMID: 25568832
PMCID: PMC4268639 DOI: 10.7453/gahmj.2014.053
Abstract
A retrospective chart review analyzed the effect of customized nutrition on the incidence of pregnancy-induced hypertension (PIH), gestational diabetes (GDM), and small- and large-for-gestational-age (SGA, LGA) neonates, examining consecutive deliveries between January 1, 2011, and Decem ber 31, 2012, at a low-risk community hospital. The population was divided into 3 groups: (1) study group (SG), (2) private practice (PP), and (3) community healthcare clinic (CHCC). All groups received standard perinatal management, but additionally the study group was analyzed for serum zinc, carnitine, total 25-hydroxy cholecalciferol (25 OH-D), methylene tetrahydrofolate reductase, and catechol-O-methyl transferase polymorphisms in the first trimester prior to intervention, with subsequent second trimester and postpartum assessment of zinc, carnitine, and 25 OH-D after intervention. Intervention consisted of trimesterby-trimester nutrition and lifestyle education, supplementation of L-methyl folate, magnesium, essential fatty acids, and probiotics for all SG patients, with targeted supplementation of zinc, carnitine, and 25 OH-D. Because of small case occurrence rates of individual conditions in the study group, unreportable reductions were found, except GDM (SG vs CHCC, P value .046 with 95.38% confidence interval [CI]), and PIH (SG vs PP, P value .0505 with 94.95% CIl). The aggregated occurrence rate of the four conditions, however, was significantly lower in the study population than in either comparison population (PP P value .0154 with 98.46% CI, and CHCC P value .0265 with 97.35% CI). Customized nutritional intervention appears to have significantly reduced adverse perinatal outcomes. Prospective study within larger, at-risk populations is needed to determine whether customized nutrition improves conditions individually.
Keywords: Nutrition; neonatal complications; observational study; pregnancy
References
- Environ Health Perspect. 2013 Oct;121(10):A298-303 - PubMed
- Int J Epidemiol. 2007 Dec;36(6):1196-204 - PubMed
- Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17589-94 - PubMed
- JAMA. 2004 Jun 2;291(21):2616-22 - PubMed
- Eur J Clin Nutr. 2009 Sep;63(9):1098-105 - PubMed
- Eur J Nutr. 2008 Aug;47 Suppl 3:38-50 - PubMed
- PLoS One. 2011;6(11):e28282 - PubMed
- Thromb Haemost. 1999 Mar;81(3):349-52 - PubMed
- J Allergy Clin Immunol. 2011 May;127(5):1087-94; quiz 1095-6 - PubMed
- EMBO Rep. 2011 Jan;12(1):30-4 - PubMed
- Arch Biochem Biophys. 2004 Mar 1;423(1):227-34 - PubMed
- J Neurosci. 2009 Oct 14;29(41):12815-23 - PubMed
- BMC Pregnancy Childbirth. 2010 Apr 25;10:17 - PubMed
- Trends Endocrinol Metab. 2002 Nov;13(9):364-8 - PubMed
- Eur J Hum Genet. 2002 Nov;10(11):682-8 - PubMed
- Clin Exp Allergy. 2013 Apr;43(4):434-42 - PubMed
- Nutr J. 2014 Jul 15;13:72 - PubMed
- Nutr Rev. 2012 Mar;70(3):153-64 - PubMed
- Curr Opin Allergy Clin Immunol. 2013 Jun;13(3):280-6 - PubMed
- Nutrients. 2012 Jul;4(7):799-840 - PubMed
- Mol Cell Endocrinol. 2001 Dec 20;185(1-2):93-8 - PubMed
- J Physiol. 2008 Apr 15;586(8):2217-29 - PubMed
- Am J Clin Nutr. 2013 Jun;97(6):1217-27 - PubMed
- Physiol Rep. 2013 Oct;1(5):e00096 - PubMed
- Epidemiology. 2011 Jul;22(4):476-85 - PubMed
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