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Leite JB, Vilela EG, da Gama Torres HO, et al. Intestinal permeability in leukemic patients prior to chemotherapy. Rev Bras Hematol Hemoter. 2014;36(6):409-13doi: 10.1016/j.bjhh.2014.07.007.
Leite, J. B., Vilela, E. G., da Gama Torres, H. O., de Lourdes de Abreu Ferrari, M., & da Cunha, A. S. (2014). Intestinal permeability in leukemic patients prior to chemotherapy. Revista brasileira de hematologia e hemoterapia, 36(6), 409-13. https://doi.org/10.1016/j.bjhh.2014.07.007
Leite, Juliana Brovini, et al. "Intestinal permeability in leukemic patients prior to chemotherapy." Revista brasileira de hematologia e hemoterapia vol. 36,6 (2014): 409-13. doi: https://doi.org/10.1016/j.bjhh.2014.07.007
Leite JB, Vilela EG, da Gama Torres HO, de Lourdes de Abreu Ferrari M, da Cunha AS. Intestinal permeability in leukemic patients prior to chemotherapy. Rev Bras Hematol Hemoter. 2014 Nov-Dec;36(6):409-13. doi: 10.1016/j.bjhh.2014.07.007. Epub 2014 Jul 17. PMID: 25453650; PMCID: PMC4318478.
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Rev Bras Hematol Hemoter. 2014 Nov-Dec;36(6):409-13. doi: 10.1016/j.bjhh.2014.07.007. Epub 2014 Jul 17.

Intestinal permeability in leukemic patients prior to chemotherapy.

Revista brasileira de hematologia e hemoterapia

Juliana Brovini Leite, Eduardo Garcia Vilela, Henrique Oswaldo da Gama Torres, Maria de Lourdes de Abreu Ferrari, Aloísio Sales da Cunha

Affiliations

  1. Universidade Federal de Minas Gerais (UFMG), Juiz de Fora, MG, Brazil. Electronic address: [email protected].
  2. Universidade Federal de Minas Gerais (UFMG), Juiz de Fora, MG, Brazil.

PMID: 25453650 PMCID: PMC4318478 DOI: 10.1016/j.bjhh.2014.07.007

Abstract

OBJECTIVE: The objective of this study was to evaluate the intestinal barrier function in leukemia patients before the start of the chemotherapy with an intestinal permeability test using lactulose and mannitol as markers.

METHODS: The study enrolled 20 patients diagnosed with leukemia (acute and chronic). Ten healthy volunteers were also submitted to the test as a control group.

RESULTS: The median lactulose/mannitol ratio was 0.019 for the Leukemia Patient Group, whereas in healthy controls the median was 0.009 (p-value=0.244). The median lactulose/mannitol ratio in acute leukemia patients was 0.034 giving a p-value of 0.069 when compared to healthy controls. This same comparison was made between acute myeloid leukemia patients and healthy controls with a p-value of 0.149. There was no significant difference in the intestinal permeability between acute and chronic leukemia patients (p-value=0.098).

CONCLUSION: The intestinal barrier function measured using the intestinal permeability test was similar in leukemic patients overall and healthy controls, but a tendency toward a different pattern was found in the intestinal barrier function of acute leukemia patients.

Copyright © 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved.

Keywords: Lactulose; Leukemia; Mannitol

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