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Verdaguer N, Ferrero D, Murthy MR. Viruses and viral proteins. IUCrJ. 2014;1:492-504doi: 10.1107/S205225251402003X.
Verdaguer, N., Ferrero, D., & Murthy, M. R. (2014). Viruses and viral proteins. IUCrJ, 1492-504. https://doi.org/10.1107/S205225251402003X
Verdaguer, Nuria, et al. "Viruses and viral proteins." IUCrJ vol. 1 (2014): 492-504. doi: https://doi.org/10.1107/S205225251402003X
Verdaguer N, Ferrero D, Murthy MR. Viruses and viral proteins. IUCrJ. 2014 Oct 14;1:492-504. doi: 10.1107/S205225251402003X. eCollection 2014 Nov 01. PMID: 25485129; PMCID: PMC4224467.
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IUCrJ. 2014 Oct 14;1:492-504. doi: 10.1107/S205225251402003X. eCollection 2014 Nov 01.

Viruses and viral proteins.

IUCrJ

Nuria Verdaguer, Diego Ferrero, Mathur R N Murthy

Affiliations

  1. Institut de Biología Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Baldiri i Reixac 15, 08028-Barcelona, Spain.
  2. Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.

PMID: 25485129 PMCID: PMC4224467 DOI: 10.1107/S205225251402003X

Abstract

For more than 30 years X-ray crystallography has been by far the most powerful approach for determining the structures of viruses and viral proteins at atomic resolution. The information provided by these structures, which covers many important aspects of the viral life cycle such as cell-receptor recognition, viral entry, nucleic acid transfer and genome replication, has extensively enriched our vision of the virus world. Many of the structures available correspond to potential targets for antiviral drugs against important human pathogens. This article provides an overview of the current knowledge of different structural aspects of the above-mentioned processes.

Keywords: RNA-dependent RNA polymerases; bacteriophages; fusion proteins; genome delivery; viral proteases; viral receptors; viruses

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