Display options
Cite
Manusow JS, Khoja L, Pesin N, et al. Retinal vasculitis and ocular vitreous metastasis following complete response to PD-1 inhibition in a patient with metastatic cutaneous melanoma. J Immunother Cancer. 2014;2(1):41doi: 10.1186/s40425-014-0041-1.
Manusow, J. S., Khoja, L., Pesin, N., Joshua, A. M., & Mandelcorn, E. D. (2014). Retinal vasculitis and ocular vitreous metastasis following complete response to PD-1 inhibition in a patient with metastatic cutaneous melanoma. Journal for immunotherapy of cancer, 2(1), 41. https://doi.org/10.1186/s40425-014-0041-1
Manusow, Joshua S, et al. "Retinal vasculitis and ocular vitreous metastasis following complete response to PD-1 inhibition in a patient with metastatic cutaneous melanoma." Journal for immunotherapy of cancer vol. 2,1 (2014): 41. doi: https://doi.org/10.1186/s40425-014-0041-1
Manusow JS, Khoja L, Pesin N, Joshua AM, Mandelcorn ED. Retinal vasculitis and ocular vitreous metastasis following complete response to PD-1 inhibition in a patient with metastatic cutaneous melanoma. J Immunother Cancer. 2014 Dec 16;2(1):41. doi: 10.1186/s40425-014-0041-1. eCollection 2014. PMID: 25516805; PMCID: PMC4266968.
Copy Download .nbib Format: NLM
Share it on

J Immunother Cancer. 2014 Dec 16;2(1):41. doi: 10.1186/s40425-014-0041-1. eCollection 2014.

Retinal vasculitis and ocular vitreous metastasis following complete response to PD-1 inhibition in a patient with metastatic cutaneous melanoma.

Journal for immunotherapy of cancer

Joshua S Manusow, Leila Khoja, Nataly Pesin, Anthony M Joshua, Efrem D Mandelcorn

Affiliations

  1. University of Toronto Department of Ophthalmology and Vision Sciences, University Health Network/Toronto Western Hospital, 399 Bathurst Street, 6 East Room 415, Toronto, Ontario M5T 2S8 Canada.
  2. Department of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Canada.

PMID: 25516805 PMCID: PMC4266968 DOI: 10.1186/s40425-014-0041-1

Abstract

We report on a 36-year-old woman treated with the anti PD-1 antibody Pembrolizumab for metastatic cutaneous melanoma in the first line setting. She achieved a complete response and then relapsed with metastases to the vitreous cavity with an associated angiographically determined retinal vasculitis. Vitreous metastasis without choroidal involvement is unusual and may be due to individual cell extravasation, vitreous hemorrhage containing malignant cells, or direct spread through the optic nerve. This finding highlights the need for immune sanctuary sites to be monitored in the presence of PD-1 inhibition and we hypothesize that the use of PD-1 inhibitor potentiated the patient's angiographically determined retinal vasculitis.

Keywords: Melanoma; Melanoma-associated Retinopathy (MAR); PD-1 inhibitor; Retinal vasculitis; Vitreous metastasis

References

  1. Ther Adv Med Oncol. 2013 Sep;5(5):278-85 - PubMed
  2. Graefes Arch Clin Exp Ophthalmol. 2007 May;245(5):733-40 - PubMed
  3. Lancet Oncol. 2012 May;13(5):459-65 - PubMed
  4. N Engl J Med. 2013 Jul 11;369(2):134-44 - PubMed
  5. Immunol Rev. 2006 Oct;213:48-65 - PubMed
  6. Ophthalmology. 1998 Apr;105(4):600-5 - PubMed
  7. Surv Ophthalmol. 2013 Sep-Oct;58(5):430-58 - PubMed
  8. Arch Ophthalmol. 2009 Dec;127(12):1572-80 - PubMed
  9. Exp Eye Res. 2008 Jan;86(1):52-9 - PubMed

Publication Types