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Raut SS, Shah SA, Patel KA, et al. Improving Outcome of Aplastic Anaemia with HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantation: An Experience of Gujarat Cancer and Research Institute (GCRI). Indian J Hematol Blood Transfus. 2014;31(1):1-8doi: 10.1007/s12288-014-0397-x.
Raut, S. S., Shah, S. A., Patel, K. A., Shah, K. M., Anand, A. S., Talati, S. S., Panchal, H. P., Patel, A. A., Parikh, S. K., Parekh, B. B., & Shukla, S. N. (2015). Improving Outcome of Aplastic Anaemia with HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantation: An Experience of Gujarat Cancer and Research Institute (GCRI). Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 31(1), 1-8. https://doi.org/10.1007/s12288-014-0397-x
Raut, Shreeniwas S, et al. "Improving Outcome of Aplastic Anaemia with HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantation: An Experience of Gujarat Cancer and Research Institute (GCRI)." Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion vol. 31,1 (2015): 1-8. doi: https://doi.org/10.1007/s12288-014-0397-x
Raut SS, Shah SA, Patel KA, Shah KM, Anand AS, Talati SS, Panchal HP, Patel AA, Parikh SK, Parekh BB, Shukla SN. Improving Outcome of Aplastic Anaemia with HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantation: An Experience of Gujarat Cancer and Research Institute (GCRI). Indian J Hematol Blood Transfus. 2015 Mar;31(1):1-8. doi: 10.1007/s12288-014-0397-x. Epub 2014 May 08. PMID: 25548437; PMCID: PMC4275516.
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Indian J Hematol Blood Transfus. 2015 Mar;31(1):1-8. doi: 10.1007/s12288-014-0397-x. Epub 2014 May 08.

Improving Outcome of Aplastic Anaemia with HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantation: An Experience of Gujarat Cancer and Research Institute (GCRI).

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Shreeniwas S Raut, Sandip A Shah, Kinnari A Patel, Kamlesh M Shah, Asha S Anand, Shailesh S Talati, Harsha P Panchal, Apurva A Patel, Sonia K Parikh, Bhavesh B Parekh, Shilin N Shukla

Affiliations

  1. Civil Hospital, GCRI, Room No. 35, P.G. Hostel, GCRI Campus, Ahmedabad, 380016 Gujarat India.

PMID: 25548437 PMCID: PMC4275516 DOI: 10.1007/s12288-014-0397-x

Abstract

Fifteen patients, with a median age of 19 years having severe aplastic anaemia (SAA) underwent human leucocyte antigen (HLA) identical sibling donor hematopoietic stem cell transplantation (HSCT) using conditioning regimens containing cyclophosphamide with antithymocyte globulin (ATG) or a combination of fludarabine and cyclophosphamide with or without ATG during December 2007 to May 2013. Cyclosporine and mini methotrexate were used as graft versus host disease (GVHD) prophylaxis. Graft source included peripheral blood stem cells in 11, bone marrow in 3 and both in 1. One patient had primary graft failure while 14 patients were engrafted with a median neutrophil and platelet engraftment time of 13.5 days. One patient had secondary graft rejection. Acute GVHD occurred in 3 patients and chronic GVHD in 4. One year death rate in engrafted patients was 14.28 %. At a mean follow-up of 21.2 months, 12 (80 %) are alive and well. One of the donors was a patient of haemophilia but the disease did not occur in the recipient. The graft was successful and the recipient is alive till date.

Keywords: Allogeneic bone marrow transplantation; Aplastic anaemia; Gujarat; HLA-matched sibling-donor; Peripheral blood stem cell transplantation

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