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Paul S, Ramalingam S, Subramaniam D, et al. Histone Demethylases in Colon Cancer. Curr Colorectal Cancer Rep. 2014;10(4):417-424doi: 10.1007/s11888-014-0253-2.
Paul, S., Ramalingam, S., Subramaniam, D., Baranda, J., Anant, S., & Dhar, A. (2014). Histone Demethylases in Colon Cancer. Current colorectal cancer reports, 10(4), 417-424. https://doi.org/10.1007/s11888-014-0253-2
Paul, Santanu, et al. "Histone Demethylases in Colon Cancer." Current colorectal cancer reports vol. 10,4 (2014): 417-424. doi: https://doi.org/10.1007/s11888-014-0253-2
Paul S, Ramalingam S, Subramaniam D, Baranda J, Anant S, Dhar A. Histone Demethylases in Colon Cancer. Curr Colorectal Cancer Rep. 2014 Dec 01;10(4):417-424. doi: 10.1007/s11888-014-0253-2. PMID: 25574158; PMCID: PMC4283932.
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Curr Colorectal Cancer Rep. 2014 Dec 01;10(4):417-424. doi: 10.1007/s11888-014-0253-2.

Histone Demethylases in Colon Cancer.

Current colorectal cancer reports

Santanu Paul, Satish Ramalingam, Dharmalingam Subramaniam, Joaquina Baranda, Shrikant Anant, Animesh Dhar

Affiliations

  1. Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.
  2. Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas.
  3. Hematology & Oncology, University of Kansas Medical Center, Kansas City, Kansas.
  4. Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas ; Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas.

PMID: 25574158 PMCID: PMC4283932 DOI: 10.1007/s11888-014-0253-2

Abstract

Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer. Colon cancer is the third most common malignancy worldwide and the second leading cause of cancer deaths in the United States. The key protein families responsible for demethylation of histones, histone demethylases, have emerged as new therapeutic targets in different cancer types including colon cancer. These families are of great interest as potential novel biomarkers for diagnosis and targets for therapy and prevention of colon cancer. In this manuscript, we will discuss our current understanding of the histone demethylase family, and the role they play as epigenetic activators or repressors of different genes in colon cancer.

Keywords: Colon Cancer; Epigenetic; Histone Lysine Demethylases; JMJD; KDM; LSD

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