Exp Ther Med. 2015 Feb;9(2):345-350. doi: 10.3892/etm.2014.2123. Epub 2014 Dec 09.
Experimental and therapeutic medicine
Jiun Kang
PMID: 25574196 PMCID: PMC4280924 DOI: 10.3892/etm.2014.2123
Genetic alterations in the early stages of cancer have a close correlation with tumor initiation and potentially activate downstream pathways implicated in tumor progression; however, the method of initiation in sporadic neoplasias is largely unknown. In this study, whole-genome microarray-comparative genomic hybridization was performed to identify the early genetic alterations that define the prognosis of patients with stage I squamous cell carcinoma (SCC) of the lung. The most striking finding was the high frequency of copy number losses and hemizygous deletions on chromosome 8p, which occurred in 94.7% (18/19) and 63.2% (12/19) of the cases, respectively, with a delineated minimal common region of 8p21.1-p23.3. More specifically, three loci of homozygous deletions at 8p23.1 were noted in 21.1% (4/19) of the cases. This region contains the following possible target genes, which have previously not been implicated to play a pathogenic role in stage I SCCs
Keywords: copy number loss; homozygous deletion; microarray-comparative genomic hybridization; squamous cell carcinoma of the lung; tumor suppressor genes
