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Li DY, Zhang HW, Feng QZ, et al. Impacts of leukocyte filtration and irradiation on coagulation factors in fresh frozen plasma. Exp Ther Med. 2014;9(2):598-602doi: 10.3892/etm.2014.2126.
Li, D. Y., Zhang, H. W., Feng, Q. Z., & Zhao, H. (2015). Impacts of leukocyte filtration and irradiation on coagulation factors in fresh frozen plasma. Experimental and therapeutic medicine, 9(2), 598-602. https://doi.org/10.3892/etm.2014.2126
Li, Dai-Yu, et al. "Impacts of leukocyte filtration and irradiation on coagulation factors in fresh frozen plasma." Experimental and therapeutic medicine vol. 9,2 (2015): 598-602. doi: https://doi.org/10.3892/etm.2014.2126
Li DY, Zhang HW, Feng QZ, Zhao H. Impacts of leukocyte filtration and irradiation on coagulation factors in fresh frozen plasma. Exp Ther Med. 2015 Feb;9(2):598-602. doi: 10.3892/etm.2014.2126. Epub 2014 Dec 10. PMID: 25574241; PMCID: PMC4280960.
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Exp Ther Med. 2015 Feb;9(2):598-602. doi: 10.3892/etm.2014.2126. Epub 2014 Dec 10.

Impacts of leukocyte filtration and irradiation on coagulation factors in fresh frozen plasma.

Experimental and therapeutic medicine

Dai-Yu Li, Hong-Wei Zhang, Qing-Zhen Feng, Hua Zhao

Affiliations

  1. Department of Blood Transfusion, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
  2. Department of Clinical Laboratory, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.

PMID: 25574241 PMCID: PMC4280960 DOI: 10.3892/etm.2014.2126

Abstract

This study aimed to compare and analyze the changes in the coagulation factors in fresh frozen plasma (FFP) prior to and following leukocyte filtration and irradiation. In total, 30 bags of FFP from healthy donors were processed: One-third of the FFP of each bag was left within the original bag (the A group), the other two-thirds of the FFP of each bag were passed through a disposable leukocyte filter, then divided equally into two parts. One of these was designated as the B group, and the other was designated the C group (subjected to 30 Gy irradiation). All samples were analyzed to evaluate 16 coagulation indicators. Analysis of variance revealed that there were statistically significant differences in the levels of fibrinogen (FbgC) and coagulation factor VIII (FVIII:C) among the groups (P=0.044 and P=0.015, respectively); the Dunnett's t-test revealed that there was a statistically significant difference in the level of FbgC between the A and B groups (P=0.025), and there was a statistically significant difference in the level of FVIII:C between the A and C groups (P=0.009); while the remaining 14 coagulation parameters were not significantly different among the groups. Although the levels of FbgC and FVIII:C in the FFP were reduced following treatment, this would not affect the clinical effect of the FFP.

Keywords: coagulation factor; coagulation system; fresh frozen plasma; irradiation; leukocyte filtration

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