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Fujimoto K, Hiraoka M, Inatomi S, et al. Association of cryptogenic organizing pneumonia in bilateral anterior uveitis. Case Rep Ophthalmol. 2014;5(3):365-72doi: 10.1159/000369125.
Fujimoto, K., Hiraoka, M., Inatomi, S., & Ohguro, H. (2014). Association of cryptogenic organizing pneumonia in bilateral anterior uveitis. Case reports in ophthalmology, 5(3), 365-72. https://doi.org/10.1159/000369125
Fujimoto, Kaori, et al. "Association of cryptogenic organizing pneumonia in bilateral anterior uveitis." Case reports in ophthalmology vol. 5,3 (2014): 365-72. doi: https://doi.org/10.1159/000369125
Fujimoto K, Hiraoka M, Inatomi S, Ohguro H. Association of cryptogenic organizing pneumonia in bilateral anterior uveitis. Case Rep Ophthalmol. 2014 Nov 13;5(3):365-72. doi: 10.1159/000369125. eCollection 2014 Sep. PMID: 25520652; PMCID: PMC4264495.
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Case Rep Ophthalmol. 2014 Nov 13;5(3):365-72. doi: 10.1159/000369125. eCollection 2014 Sep.

Association of cryptogenic organizing pneumonia in bilateral anterior uveitis.

Case reports in ophthalmology

Kaori Fujimoto, Miki Hiraoka, Shuichiro Inatomi, Hiroshi Ohguro

Affiliations

  1. Department of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

PMID: 25520652 PMCID: PMC4264495 DOI: 10.1159/000369125

Abstract

Two female patients with histories of cancer who showed cryptogenic organizing pneumonia (COP) complications and bilateral anterior uveitis with hypopyon were examined. Both patients had suffered from COP and received intermitted systemic corticosteroid administration (SCA). The first patient, a 65-year-old woman with a history of breast cancer, showed bilateral uveitis with hypopyon. The topical corticosteroid treatment was ineffective. After SCA for the treatment of COP was started, the hypopyon gradually dissipated. Upon termination of SCA, uveitis relapses were controlled by renewed SCA. The other patient, a 69-year-old woman with a history of ovarian cancer, showed bilateral anterior uveitis with hypopyon. Her intraocular outcome did not improve by the topical corticosteroid administration, but SCA that was applied to treat COP led to remission of uveitis. Imaging examinations, biochemical analysis, symptoms or HLA-B27 antigen screenings in either patient did not explain the development of uveitis. Bilateral anterior uveitis is commonly related to autoimmune disease or systemic syndrome. We report two cases with COP that developed bilateral anterior uveitis with hypopyon resistant to topical administration but responsive to systemic administration of corticosteroid. These findings suggest that COP can be associated with the etiology of anterior uveitis.

Keywords: Bilateral uveitis; Cryptogenic organizing pneumonia; Hypopyon; Systemic corticosteroid administration

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