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Verlengia R, Rebelo AC, Crisp AH, et al. Lack of Association Between ACE Indel Polymorphism and Cardiorespiratory Fitness in Physically Active and Sedentary Young Women. Asian J Sports Med. 2014;5(3):e22768doi: 10.5812/asjsm.22768.
Verlengia, R., Rebelo, A. C., Crisp, A. H., Kunz, V. C., Dos Santos Carneiro Cordeiro, M. A., Hirata, M. H., Crespo Hirata, R. D., & Silva, E. (2014). Lack of Association Between ACE Indel Polymorphism and Cardiorespiratory Fitness in Physically Active and Sedentary Young Women. Asian journal of sports medicine, 5(3), e22768. https://doi.org/10.5812/asjsm.22768
Verlengia, Rozangela, et al. "Lack of Association Between ACE Indel Polymorphism and Cardiorespiratory Fitness in Physically Active and Sedentary Young Women." Asian journal of sports medicine vol. 5,3 (2014): e22768. doi: https://doi.org/10.5812/asjsm.22768
Verlengia R, Rebelo AC, Crisp AH, Kunz VC, Dos Santos Carneiro Cordeiro MA, Hirata MH, Crespo Hirata RD, Silva E. Lack of Association Between ACE Indel Polymorphism and Cardiorespiratory Fitness in Physically Active and Sedentary Young Women. Asian J Sports Med. 2014 Sep;5(3):e22768. doi: 10.5812/asjsm.22768. Epub 2014 Aug 28. PMID: 25520764; PMCID: PMC4267487.
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Asian J Sports Med. 2014 Sep;5(3):e22768. doi: 10.5812/asjsm.22768. Epub 2014 Aug 28.

Lack of Association Between ACE Indel Polymorphism and Cardiorespiratory Fitness in Physically Active and Sedentary Young Women.

Asian journal of sports medicine

Rozangela Verlengia, Ana C Rebelo, Alex H Crisp, Vandeni C Kunz, Marco A Dos Santos Carneiro Cordeiro, Mario H Hirata, Rosario D Crespo Hirata, Ester Silva

Affiliations

  1. College of Health Sciences, Methodist University of Piracicaba, Piracicaba, Brazil.
  2. Department of Morphology, Federal University of Goias, Goiania, Brazil.
  3. Adventist University of Sao Paulo, Engenheiro Coellho, Sao Paulo, Brazil.
  4. School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
  5. Department of Physiotherapy, Federal University of Sao Carlos, Sao Carlos, Brazil.

PMID: 25520764 PMCID: PMC4267487 DOI: 10.5812/asjsm.22768

Abstract

BACKGROUND: Polymorphisms at the angiotensin-converting enzyme gene (ACE), such as the indel [rs1799752] variant in intron 16, have been shown to be associated with aerobic performance of athletes and non-athletes. However, the relationship between ACE indel polymorphism and cardiorespiratory fitness has not been always demonstrated.

OBJECTIVES: The relationship between ACE indel polymorphism and cardiorespiratory fitness was investigated in a sample of young Caucasian Brazilian women.

PATIENTS AND METHODS: This study investigated 117 healthy women (aged 18 to 30 years) who were grouped as physically active (n = 59) or sedentary (n = 58). All subjects performed an incremental exercise test (ramp protocol) on a cycle-ergometer with 20-25 W/min increments. Blood samples were obtained for DNA extraction and to analyze metabolic and hormonal profiles. ACE indel polymorphism was determined by polymerase chain reaction (PCR) and fragment size analysis.

RESULTS: The physically active group had higher values of peak oxygen uptake (VO2 peak), carbon dioxide output (VCO2), ventilation (VE) and power output than the sedentary group (P < 0.05) at the peak of the exercise test. However, heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) did not differ between groups. There was no relationship between ACE indel polymorphism and cardiorespiratory variables during the test in both the physically active and sedentary groups, even when the dominant (DD vs. D1 + 2) and recessive (2 vs. DI + DD) models of inheritance were tested.

CONCLUSIONS: These results do not support the concept that the genetic variation at the ACE locus contributes to the cardiorespiratory responses at the peak of exercise test in physically active or sedentary healthy women. This indicates that other factors might mediate these responses, including the physical training level of the women.

Keywords: Angiotensin-Converting Enzyme; Exercise Test; Motor Activity; Polymorphism, Genetic

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