Display options
Cite
Fornari MB, Zanella R, Ibelli AM, et al. Unraveling the associations of osteoprotegerin gene with production traits in a paternal broiler line. Springerplus. 2014;3:682doi: 10.1186/2193-1801-3-682.
Fornari, M. B., Zanella, R., Ibelli, A. M., Fernandes, L. T., Cantão, M. E., Thomaz-Soccol, V., Ledur, M. C., & Peixoto, J. O. (2014). Unraveling the associations of osteoprotegerin gene with production traits in a paternal broiler line. SpringerPlus, 3682. https://doi.org/10.1186/2193-1801-3-682
Fornari, Marcelo B, et al. "Unraveling the associations of osteoprotegerin gene with production traits in a paternal broiler line." SpringerPlus vol. 3 (2014): 682. doi: https://doi.org/10.1186/2193-1801-3-682
Fornari MB, Zanella R, Ibelli AM, Fernandes LT, Cantão ME, Thomaz-Soccol V, Ledur MC, Peixoto JO. Unraveling the associations of osteoprotegerin gene with production traits in a paternal broiler line. Springerplus. 2014 Nov 20;3:682. doi: 10.1186/2193-1801-3-682. eCollection 2014. PMID: 25520909; PMCID: PMC4247828.
Copy Download .nbib Format: NLM
Share it on

Springerplus. 2014 Nov 20;3:682. doi: 10.1186/2193-1801-3-682. eCollection 2014.

Unraveling the associations of osteoprotegerin gene with production traits in a paternal broiler line.

SpringerPlus

Marcelo B Fornari, Ricardo Zanella, Adriana Mg Ibelli, Lana T Fernandes, Maurício E Cantão, Vanete Thomaz-Soccol, Mônica C Ledur, Jane O Peixoto

Affiliations

  1. Departamento de Engenharia de Bioprocessos e Biotecnologia, Universidade Federal do Paraná, Curitiba, PR Brazil.
  2. Laboratório de Genética e Melhoramento Animal, Embrapa Suínos e Aves, BR 153, km 110, Distrito de Tamanduá, Caixa Postal 21, 89700-000 Concórdia, SC Brazil.

PMID: 25520909 PMCID: PMC4247828 DOI: 10.1186/2193-1801-3-682

Abstract

Improvements on growth and carcass traits in the poultry industry have been achieved by intense selection for heavier chickens at early ages. This faster growth has caused serious problems due to insufficient skeletal structure development needed to support the musculature of modern broilers. The osteoprotegerin gene (OPG), located on GGA2, is an important regulator of bone metabolism and reabsorption, being suggestive as a possible functional candidate gene associated with bone integrity in chickens. This study reports associations of a single nucleotide polymorphism (SNP) in the OPG gene with production traits in a parental broiler line. Different phenotypic groups were evaluated: performance, carcass and skeletal traits. SNPs were identified within the OPG gene and the most informative SNP g.9144C > G was chosen for association analyses. Chickens (n = 1230) were genotyped using PCR-RFLP. The association was carried out with QxPaK v4.0 software using a mixed model including sex, hatch and SNP as fixed effects, and the infinitesimal and residual as random effects. The OPG SNP was associated with important traits as body weight at 21 days, weights of tibia and drumstick skin, leg muscle yield, and tibia breaking strength (P < 0.05). Associations were explained by the additive effect of the SNP and the additive effect within sex. This SNP could be considered a potential marker to improve bone resistance in chickens; however, caution should be taken because of its negative effect in other important traits evaluated in this study. Furthermore, these findings suggest a possible involvement of the OPG gene in fat deposition in poultry.

Keywords: Bone metabolism; Bone resistance; Chicken; Fat deposition; TNFRSF11B

References

  1. Mol Genet Metab. 2003 Nov;80(3):344-9 - PubMed
  2. Poult Sci. 2006 Jul;85(7):1169-72 - PubMed
  3. Genome Res. 1998 Mar;8(3):195-202 - PubMed
  4. Poult Sci. 2003 Oct;82(10):1500-8 - PubMed
  5. Biochem Biophys Res Commun. 1997 May 8;234(1):137-42 - PubMed
  6. J Clin Endocrinol Metab. 2002 Apr;87(4):1443-50 - PubMed
  7. Poult Sci. 2008 Oct;87(10):1927-8 - PubMed
  8. Poult Sci. 2009 Apr;88(4):722-7 - PubMed
  9. Trends Mol Med. 2006 Jan;12(1):17-25 - PubMed
  10. Anim Genet. 2006 Jun;37(3):283-6 - PubMed
  11. Nature. 2003 May 15;423(6937):337-42 - PubMed
  12. J Bone Miner Res. 2006 Oct;21(10):1648-56 - PubMed
  13. Nucleic Acids Res. 2013 Jul;41(Web Server issue):W115-22 - PubMed
  14. J Clin Endocrinol Metab. 2010 Aug;95(8):3569-77 - PubMed
  15. Cell. 1997 Apr 18;89(2):309-19 - PubMed
  16. Poult Sci. 2000 Jul;79(7):1024-32 - PubMed
  17. Nucleic Acids Res. 2003 Jul 1;31(13):3688-91 - PubMed
  18. Gen Comp Endocrinol. 2008 Jan 15;155(2):432-7 - PubMed
  19. Endocr Rev. 1994 Jun;15(3):275-300 - PubMed
  20. Anim Genet. 2009 Oct;40(5):743-8 - PubMed
  21. Poult Sci. 2000 Jul;79(7):982-4 - PubMed
  22. Endocrinology. 1999 Sep;140(9):4367-70 - PubMed
  23. J Clin Endocrinol Metab. 2007 May;92(5):1640-6 - PubMed
  24. Anim Genet. 2007 Feb;38(1):45-9 - PubMed
  25. Genet Sel Evol. 2005 Nov-Dec;37(6):677-98 - PubMed
  26. Br Poult Sci. 2005 Aug;46(4):430-42 - PubMed
  27. J Cell Biochem. 2006 Aug 1;98(5):1123-9 - PubMed
  28. J Anim Breed Genet. 2010 Dec;127(6):462-8 - PubMed
  29. Hum Genet. 2006 Jan;118(5):568-77 - PubMed
  30. Poult Sci. 2004 Apr;83(4):521-5 - PubMed
  31. Poult Sci. 2007 Feb;86(2):255-66 - PubMed
  32. J Bone Miner Res. 2007 Jul;22(7):1062-71 - PubMed
  33. Poult Sci. 2003 Mar;82(3):347-56 - PubMed
  34. Poult Sci. 2013 Jun;92(6):1443-53 - PubMed
  35. Osteoporos Int. 2008 Jul;19(7):905-12 - PubMed
  36. Bioinformatics. 2004 Nov 1;20(16):2792-8 - PubMed
  37. Genome Res. 1998 Mar;8(3):175-85 - PubMed

Publication Types