Display options
Cite
Chou TC. New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker. Biomedicine (Taipei). 2014;4:24doi: 10.7603/s40681-014-0024-z.
Chou, T. C. (2014). New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker. BioMedicine, 424. https://doi.org/10.7603/s40681-014-0024-z
Chou, Tz-Chong. "New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker." BioMedicine vol. 4 (2014): 24. doi: https://doi.org/10.7603/s40681-014-0024-z
Chou TC. New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker. Biomedicine (Taipei). 2014;4:24. doi: 10.7603/s40681-014-0024-z. Epub 2014 Nov 18. PMID: 25520937; PMCID: PMC4265014.
Copy Download .nbib Format: NLM
Share it on

Biomedicine (Taipei). 2014;4:24. doi: 10.7603/s40681-014-0024-z. Epub 2014 Nov 18.

New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker.

BioMedicine

Tz-Chong Chou

Affiliations

  1. Institute of Medical Sciences, Tzu Chi University, 6F, Xie-Li Building, No. 707, Sec. 3, Zhongyang Rd.,, 970 Hualien, Taiwan.

PMID: 25520937 PMCID: PMC4265014 DOI: 10.7603/s40681-014-0024-z

Abstract

Platelet hyperactivity often occursd in hypertensive patients and is a key factor in the development of cardiovascular diseases including thrombosis and atherosclerosis. Nifedipine, an L-type calcium channel blocker, is widely used for hypertension and coronary heart disease therapy. In addition, nifedipine is known to exhibit an antiplatelet activity, but the underlying mechanisms involved remain unclear. Several transcription factors such as peroxisome proliferator-activated receptors (PPARs) and nuclear factor kappa B (NF-κB) exist in platelets and have an ability to regulate platelet aggregation through a non-genomic mechanism. The present article focuses on describing the mechanisms of the antiplatelet activity of nifedipine

Keywords: Nifedipine; Nitric oxide; Nuclear factor-κB; Peroxisome; Platelet aggregation; Protein kinase Cα; proliferator-activated; receptors

References

  1. Curr Opin Pharmacol. 2003 Apr;3(2):186-91 - PubMed
  2. Postepy Biochem. 2007;53(4):344-55 - PubMed
  3. J Thromb Haemost. 2013 Jun;11 Suppl 1:330-9 - PubMed
  4. Trends Cardiovasc Med. 2008 Feb;18(2):57-61 - PubMed
  5. Circ Res. 2007 Sep 28;101(7):654-62 - PubMed
  6. J Thromb Haemost. 2006 Nov;4(11):2317-26 - PubMed
  7. J Hypertens. 2014 Jan;32(1):181-92 - PubMed
  8. J Biol Chem. 2007 Sep 21;282(38):27960-9 - PubMed
  9. Br J Nutr. 2006 Feb;95(2):435-40 - PubMed
  10. Crit Care Med. 2002 May;30(5 Suppl):S332-40 - PubMed
  11. Blood Rev. 2009 Jul;23(4):177-89 - PubMed
  12. J Thromb Haemost. 2012 Feb;10(2):167-76 - PubMed
  13. Biochim Biophys Acta. 2007 Aug;1771(8):926-35 - PubMed
  14. Thromb Res. 2000 Feb 15;97(4):191-9 - PubMed
  15. Br J Pharmacol. 2014 Mar;171(6):1490-1500 - PubMed
  16. Cell. 1995 Dec 1;83(5):803-12 - PubMed
  17. Am J Hypertens. 2010 Mar;23(3):229-36 - PubMed
  18. J Clin Invest. 1996 Oct 15;98(8):1897-905 - PubMed
  19. J Agric Food Chem. 2010 Aug 11;58(15):8596-603 - PubMed
  20. J Thromb Haemost. 2009 Aug;7(8):1333-43 - PubMed
  21. Platelets. 2007 Jun;18(4):245-8 - PubMed
  22. Cardiovasc Drug Rev. 2001 Summer;19(2):87-96 - PubMed
  23. Hypertension. 2001 Jun;37(6):1410-3 - PubMed
  24. Thromb Haemost. 2005 Sep;94(3):488-92 - PubMed
  25. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4888-93 - PubMed
  26. Mol Cell Biol. 2000 Mar;20(5):1692-8 - PubMed
  27. J Biol Chem. 2005 Feb 25;280(8):7194-205 - PubMed
  28. Circulation. 2006 Sep 5;114(10):1070-7 - PubMed
  29. J Agric Food Chem. 2011 Apr 13;59(7):3050-9 - PubMed
  30. N Engl J Med. 2007 Dec 13;357(24):2482-94 - PubMed
  31. Transfus Apher Sci. 2003 Jun;28(3):269-77 - PubMed
  32. Cell. 1995 Dec 1;83(5):813-9 - PubMed
  33. J Biol Chem. 1997 Feb 7;272(6):3406-10 - PubMed
  34. J Biol Chem. 2000 Jan 21;275(3):1763-72 - PubMed
  35. Blood. 2003 Jul 15;102(2):449-61 - PubMed
  36. Blood Rev. 1995 Sep;9(3):143-56 - PubMed
  37. Blood. 1999 Dec 1;94(11):3800-5 - PubMed
  38. Clin Chem Lab Med. 2010 Dec;48 Suppl 1:S3-13 - PubMed
  39. J Thromb Haemost. 2005 Aug;3(8):1800-14 - PubMed
  40. Thromb Haemost. 2009 Aug;102(2):248-57 - PubMed
  41. Br J Pharmacol. 2002 Jan;135(2):511-9 - PubMed
  42. J Thromb Haemost. 2010 Mar;8(3):454-62 - PubMed
  43. Arterioscler Thromb Vasc Biol. 2009 May;29(5):706-11 - PubMed
  44. Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1598-605 - PubMed
  45. J Thromb Haemost. 2010 Mar;8(3):577-87 - PubMed
  46. J Biol Chem. 1998 Oct 2;273(40):25573-80 - PubMed
  47. Thromb Haemost. 1994 Aug;72(2):309-12 - PubMed
  48. Mol Med Rep. 2013 Dec;8(6):1611-6 - PubMed
  49. Nature. 2001 Jan 11;409(6817):202-7 - PubMed
  50. Pharmacol Rev. 1991 Jun;43(2):109-42 - PubMed
  51. Mol Pharmacol. 1990 May;37(5):671-81 - PubMed
  52. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):403-12 - PubMed
  53. Br J Haematol. 2002 Dec;119(4):1033-41 - PubMed
  54. J Clin Invest. 2001 Jan;107(1):7-11 - PubMed
  55. Circ Res. 1998 Nov 30;83(11):1097-103 - PubMed
  56. Circulation. 2002 Mar 26;105(12):e74 - PubMed
  57. Br J Haematol. 2008 Aug;142(4):515-28 - PubMed
  58. Thromb Haemost. 2001 Jul;86(1):427-43 - PubMed
  59. Platelets. 2009 Nov;20(7):478-86 - PubMed
  60. J Intern Med. 2007 Aug;262(2):184-98 - PubMed
  61. J Atheroscler Thromb. 2012;19(8):693-704 - PubMed
  62. J Biol Chem. 1995 Jun 2;270(22):12953-6 - PubMed
  63. Biochem Pharmacol. 2000 Oct 15;60(8):1245-50 - PubMed
  64. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7 - PubMed
  65. Lijec Vjesn. 2001 Jan-Feb;123(1-2):26-31 - PubMed
  66. Cardiovasc Res. 2005 Mar 1;65(4):907-12 - PubMed
  67. Biochem Pharmacol. 1999 Nov 15;58(10):1657-63 - PubMed
  68. J Thromb Haemost. 2009 Jul;7 Suppl 1:187-90 - PubMed
  69. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):267-73 - PubMed
  70. Biochem Soc Trans. 2007 Nov;35(Pt 5):1005-8 - PubMed
  71. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:3-58 - PubMed

Publication Types