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Mohammadi AA, Mohammadian Panah M, Pakyari MR, et al. Surgical excision followed by low dose rate radiotherapy in the management of resistant keloids. World J Plast Surg. 2013;2(2):81-6
Mohammadi, A. A., Mohammadian Panah, M., Pakyari, M. R., Tavakol, R., Ahrary, I., Seyed Jafari, S. M., & Sharifian, M. (2013). Surgical excision followed by low dose rate radiotherapy in the management of resistant keloids. World journal of plastic surgery, 2(2), 81-6.
Mohammadi, Ali Akbar, et al. "Surgical excision followed by low dose rate radiotherapy in the management of resistant keloids." World journal of plastic surgery vol. 2,2 (2013): 81-6.
Mohammadi AA, Mohammadian Panah M, Pakyari MR, Tavakol R, Ahrary I, Seyed Jafari SM, Sharifian M. Surgical excision followed by low dose rate radiotherapy in the management of resistant keloids. World J Plast Surg. 2013 Jun;2(2):81-6. PMID: 25489509; PMCID: PMC4238340.
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World J Plast Surg. 2013 Jun;2(2):81-6.

Surgical excision followed by low dose rate radiotherapy in the management of resistant keloids.

World journal of plastic surgery

Ali Akbar Mohammadi, Mohammad Mohammadian Panah, Mohammad Reza Pakyari, Raziyeh Tavakol, Iman Ahrary, Seyed Morteza Seyed Jafari, Maryam Sharifian

Affiliations

  1. Shiraz Burn Research Center, Division of Plastic and Reconstructive Surgery, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran;
  2. Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 25489509 PMCID: PMC4238340

Abstract

BACKGROUND: Depending on the cause, 40-90% of every deep dermis insult ends up in scar formation. Several modalities have been suggested as a treatment but a high rate of recurrence is reported in most of those interventions. High dose radiotherapy has been shown to be effective in reducing the recurrence rate. This study tried to determine the effectiveness of low dose rate radiotherapy following surgical excision in treating resistant keloids.

METHODS: Between January 2008 and April 2011, seventeen patients (mostly burn patients) with 26 keloids went through surgical resection followed by radiotherapy. A total dose of 15 Gy in 5 fractions was administered to the areas of scar formation.

RESULTS: All patients were followed for at least 11 months (mostly for 20 months). No recurrence occurred. There was no complication or adverse effect.

CONCLUSION: Surgical excision followed by low dose postoperative radiotherapy was an efficient treatment for keloids that were resistant to many other modalities.

Keywords: Keloid; Radiotherapy; Surgical excision

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