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Berardi AC, Oliva F, Berardocco M, et al. Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes. Muscles Ligaments Tendons J. 2014;4(3):285-91
Berardi, A. C., Oliva, F., Berardocco, M., la Rovere, M., Accorsi, P., & Maffulli, N. (2014). Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes. Muscles, ligaments and tendons journal, 4(3), 285-91.
Berardi, Anna C, et al. "Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes." Muscles, ligaments and tendons journal vol. 4,3 (2014): 285-91.
Berardi AC, Oliva F, Berardocco M, la Rovere M, Accorsi P, Maffulli N. Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes. Muscles Ligaments Tendons J. 2014 Nov 17;4(3):285-91. eCollection 2014 Jul. PMID: 25489544; PMCID: PMC4241417.
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Muscles Ligaments Tendons J. 2014 Nov 17;4(3):285-91. eCollection 2014 Jul.

Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes.

Muscles, ligaments and tendons journal

Anna C Berardi, Francesco Oliva, Martina Berardocco, Marina la Rovere, Patrizia Accorsi, Nicola Maffulli

Affiliations

  1. UOC Immunohematology and Transfusion Medicine Laboratories, Laboratory of Stem Cells, Spirito Santo Hospital, Pescara, Italy.
  2. Department of Orthopedics and Traumatology, University of Rome "Tor Vergata", School of Medicine, Rome, Italy.
  3. UOC Immunohematology and Transfusion Medicine Laboratories, Spirito Santo Hospital, Pescara, Italy.
  4. Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, Salerno, Italy; and Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Institute of Health Sciences Education, Centre for Sports and Exercise, London, UK.

PMID: 25489544 PMCID: PMC4241417

Abstract

BACKGROUND: we previously demonstrated the presence of high levels of thyroid hormones (THs) receptors isoforms in healthy tendons, their protective action during tenocyte apoptosis, and the capability to enhance tenocyte proliferation in vitro. In the present study we tested the ability of THs to influence ECM protein tenocyte secretion in an in vitro system.

METHODS: primary tenocyte-like cells were cultivated for 1, 7 and 14 days in the presence of T3 or T4 individually or in combination with ascorbic acid (AA).

RESULTS: THs (T3 or T4) in synergism with AA increase significantly the total collagen production after 14 days. THs in synergism with AA increase significantly the expression of collagen I,biglycan and COMP, after some days.

CONCLUSION: THs play a role on the extra cellular matrix of tendons, enhancing in vitro the production of several proteins such as collagen I, biglycan and COMP. THs receptors are active on human tenocytes, and can play a role in tendon ailments.

Keywords: COMP; ascorbic acid; collagen I; tendons; tenocytes; thyroid hormones

References

  1. Orthop Surg. 2013 Nov;5(4):289-92 - PubMed
  2. Arch Intern Med. 1961 Nov;108:751-6 - PubMed
  3. J Biol Chem. 1998 Aug 7;273(32):20397-403 - PubMed
  4. J Orthop Res. 2001 Mar;19(2):269-77 - PubMed
  5. Connect Tissue Res. 2012;53(5):343-8 - PubMed
  6. J Bioenerg Biomembr. 1994 Aug;26(4):393-8 - PubMed
  7. J Histochem Cytochem. 1985 Aug;33(8):737-43 - PubMed
  8. Cold Spring Harb Perspect Biol. 2011 Oct 01;3(10):a009712 - PubMed
  9. Tissue Eng. 2006 Jul;12(7):1843-9 - PubMed
  10. Front Cell Neurosci. 2013 Aug 12;7:125 - PubMed
  11. J Clin Endocrinol Metab. 1996 Aug;81(8):2976-9 - PubMed
  12. Muscles Ligaments Tendons J. 2014 Feb 24;3(4):250-2 - PubMed
  13. In Vitro Cell Dev Biol Anim. 1998 Apr;34(4):280-2 - PubMed
  14. J Endocrinol. 2006 May;189(2):189-97 - PubMed
  15. FEBS Lett. 1994 Nov 7;354(2):237-40 - PubMed
  16. J Endocrinol. 2011 Nov;211(2):109-21 - PubMed
  17. Endocrinology. 1999 Sep;140(9):4221-7 - PubMed
  18. Dev Biol. 2006 Mar 15;291(2):342-55 - PubMed
  19. J Biol Chem. 2001 Feb 23;276(8):6046-55 - PubMed
  20. Muscles Ligaments Tendons J. 2013 May 21;3(1):2-6 - PubMed
  21. Clin Endocrinol (Oxf). 2002 Oct;57(4):515-21 - PubMed
  22. J Biomech. 2004 Jun;37(6):865-77 - PubMed
  23. PLoS One. 2013 Oct 09;8(10):e74942 - PubMed
  24. Cell Death Dis. 2013 Jul 04;4:e705 - PubMed
  25. Muscles Ligaments Tendons J. 2013 May 21;3(1):12-22 - PubMed
  26. Eur Cell Mater. 2011 Jun 20;21:548-57 - PubMed
  27. Muscles Ligaments Tendons J. 2013 May 21;3(1):23-34 - PubMed
  28. J Biol Chem. 1992 Nov 5;267(31):22346-50 - PubMed
  29. Mol Cell Biochem. 2010 May;338(1-2):215-24 - PubMed
  30. J Biol Chem. 2007 Oct 26;282(43):31166-73 - PubMed
  31. J Biol Chem. 1999 Apr 2;274(14 ):9636-47 - PubMed
  32. Brain Res Dev Brain Res. 2001 Jan 31;126(1):121-4 - PubMed
  33. Am J Sports Med. 2000 Jul-Aug;28(4):499-505 - PubMed
  34. FEBS Lett. 1984 Aug 20;174(1):34-7 - PubMed
  35. J Biomech Eng. 1999 Dec;121(6):598-604 - PubMed
  36. J Rheumatol Suppl. 2004 Apr;70:45-9 - PubMed
  37. Proc Natl Acad Sci U S A. 1981 May;78(5):2879-82 - PubMed
  38. Connect Tissue Res. 2013;54(1):62-9 - PubMed
  39. J Biol Chem. 1992 Mar 25;267(9):6137-41 - PubMed
  40. Muscles Ligaments Tendons J. 2013 Jul 09;3(2):70-9 - PubMed
  41. J Shoulder Elbow Surg. 2007 Mar-Apr;16(2):169-73 - PubMed
  42. J Mol Biol. 2000 Jan 28;295(4):891-902 - PubMed
  43. J Biol Chem. 2014 Feb 21;289(8):4919-27 - PubMed
  44. Endocrinology. 1999 Nov;140(11):5014-21 - PubMed
  45. Cell Mol Neurobiol. 2008 Sep;28(6):795-801 - PubMed
  46. Foot Ankle Surg. 2014 Sep;20(3):154-9 - PubMed
  47. J Biol Chem. 1992 Mar 25;267(9):6132-6 - PubMed
  48. Circ Res. 1992 Oct;71(4):831-9 - PubMed
  49. J Biol Chem. 2002 Dec 20;277(51):49311-8 - PubMed
  50. Am J Ophthalmol. 2006 Jul;142(1):147-153 - PubMed
  51. Med Sport Sci. 2012;57:53-64 - PubMed
  52. J Endocrinol. 1997 Jul;154(1):167-75 - PubMed

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