N Am J Med Sci. 2014 Oct;6(10):510-5. doi: 10.4103/1947-2714.143282.
Glycogen and the propensity for atrial fibrillation: intrinsic anatomic differences in glycogen in the left and right atria in the goat heart.
North American journal of medical sciences
Abraham A Embi, Benjamin J Scherlag, Jerry W Ritchey
Affiliations
Affiliations
- Independent, Miami, Florida, USA.
- Heart Rhythm Institute, University of Oklahoma Health Science Center, Professor of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA.
- Professor of Pathology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater Oklahoma, USA.
PMID: 25489563
PMCID: PMC4215488 DOI: 10.4103/1947-2714.143282
Abstract
BACKGROUND: Previous experimental studies have demonstrated electrophysiological and structural remodeling in pacing induced atrial fibrillation. The latter has been characterized by glycogen accumulation but no connection to atrial fibrillation induction and maintenance has as yet been proposed.
AIMS: We determined the presence of glycogen in the right and left atrial appendages in the goat heart, in order to find any intrinsic disparity in distribution and concentration between these sites.
MATERIALS AND METHODS: Atrial appendages from 5 goats were stained by the Periodic acid Schiffmethod to determine the presence of glycogen and the concentration of glycogen by morphometric analysis.
RESULTS: We are reporting for the first time that the right atrial appendage showed scattered glycogen granules throughout the atrial myocytes which delineated the intercalated discs; whereas glycogen in the left atrial appendage was more dense within cells and coalesced against the intercalated discs and side to side junctions between myocytes. Also, morphometric analysis determined that the stained regions of the right atrial appendages averaged, 0.8 ± 1.3 μm(2) compared to the left atrial appendage sections, 2.6 ± 3 μm(2), P = 0.02. We show that glycogen is heterogeneously distributed in both atria in the normal goat heart; however, the density of glycogen deposits concentrating against the intercalated discs and side to side connections in the left atrial appendage is a critically distinct difference. Impediment of cell to cell conduction could result in a non-uniform wavefront of activation, with areas of slowed conduction, predisposing the left atrium to reentrant based atrial fibrillation.
CONCLUSION: These findings provide a basis for the well-known greater propensity for atrial fibrillation in the left versus the right atrium.
Keywords: Atrial appendages; activation wavefront; atrial conduction; atrial fibrillation; glycogen concentration; glycogen distribution
References
- Cardiovasc Pathol. 2013 Jan-Feb;22(1):58-64 - PubMed
- Circulation. 1973 Jan;47(1):178-89 - PubMed
- Circ J. 2007 Oct;71(10):1629-35 - PubMed
- J Anat. 1965 Jan;99:27-46 - PubMed
- J Biol Chem. 2002 Feb 15;277(7):4831-8 - PubMed
- Hum Pathol. 2005 Oct;36(10):1080-9 - PubMed
- Circulation. 2003 Apr 22;107(15):2051-8 - PubMed
- Europace. 2010 Feb;12(2):160-72 - PubMed
- Am J Pathol. 1997 Oct;151(4):985-97 - PubMed
- Cardiovasc Diabetol. 2007 Nov 27;6:36 - PubMed
- Circulation. 1995 Oct 1;92(7):1954-68 - PubMed
- Eur Heart J. 1994 Apr;15 Suppl A:2-8 - PubMed
- Circulation. 2000 Jan 18;101(2):194-9 - PubMed
- Circ Res. 1983 Feb;52(2):188-99 - PubMed
- Circulation. 2002 Jul 16;106(3):331-6 - PubMed
- Nat Methods. 2012 Jul;9(7):671-5 - PubMed
- Circ Arrhythm Electrophysiol. 2013 Dec;6(6):1208-14 - PubMed
- Eur Heart J. 2006 Sep;27(17 ):2062-8 - PubMed
- Circulation. 2006 Dec 5;114(23):2434-42 - PubMed
- Pacing Clin Electrophysiol. 2012 Feb;35(2):188-95 - PubMed
- EMBO J. 2002 Jul 15;21(14 ):3598-607 - PubMed
- Clin J Am Soc Nephrol. 2009 Nov;4(11):1741-6 - PubMed
- J Thorac Cardiovasc Surg. 1991 Apr;101(4):569-83 - PubMed
- Circ Res. 1988 Apr;62(4):811-32 - PubMed
- Circulation. 2001 May 29;103(21):2631-6 - PubMed
- J Am Coll Cardiol. 2005 Jun 7;45(11):1878-86 - PubMed
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