N Am J Med Sci. 2014 Oct;6(10):519-31. doi: 10.4103/1947-2714.143284.
Thimerosal-containing hepatitis B vaccination and the risk for diagnosed specific delays in development in the United States: a case-control study in the vaccine safety datalink.
North American journal of medical sciences
David A Geier, Janet K Kern, Brian S Hooker, Paul G King, Lisa K Sykes, Mark R Geier
Affiliations
Affiliations
- Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA.
- Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA ; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
- Biology Department, Simpson University, Redding, California, USA.
- CoMeD, Inc, Silver Spring, Maryland, USA.
PMID: 25489565
PMCID: PMC4215490 DOI: 10.4103/1947-2714.143284
Abstract
BACKGROUND: Within the first 3 years of life, the brain develops rapidly. Its development is characterized by critical developmental periods for speech, vision, hearing, language, balance, etc.; and alteration in any of the processes occurring in those critical periods can lead to specific delays in development.
AIMS: The present study evaluated the potential toxic effects of organic-mercury exposure from Thimerosal (49.55% mercury by weight) in childhood vaccines and its hypothesized possible relationship with specific delays in development.
MATERIALS AND METHODS: A hypothesis testing case-control study was undertaken to evaluate the relationship between exposure to Thimerosal-containing hepatitis B vaccines administered at specific intervals in the first 6 months among cases diagnosed with specific delays in development and controls born between 1991-2000, utilizing data in the Vaccine Safety Datalink database.
RESULTS: Cases were significantly more likely than controls to have received increased organic-mercury from Thimerosal-containing hepatitis B vaccine administered in the first, second, and sixth month of life.
CONCLUSION: Though routine childhood vaccination may be an important public health tool to reduce the morbidity and mortality associated with infectious diseases, the present study supports an association between increasing organic-mercury exposure from Thimerosal-containing childhood vaccines and the subsequent risk of specific delays in development among males and females.
Keywords: Ethylmercury; Merthiolate; Thimerosal; Thiomersal; Vaccine
References
- Arch Toxicol. 2010 Nov;84(11):891-6 - PubMed
- Mol Psychiatry. 2004 Sep;9(9):833-45 - PubMed
- Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3045-53 - PubMed
- J Toxicol Environ Health A. 2010;73(19):1298-313 - PubMed
- J Pediatr. 2009 Oct;155(4):495-9 - PubMed
- Pediatrics. 2009 Feb;123(2):475-82 - PubMed
- Cell Biol Toxicol. 2013 Aug;29(4):239-57 - PubMed
- Med Sci Monit. 2005 Apr;11(4):CR160-70 - PubMed
- Neural Plast. 2011;2011:921680 - PubMed
- World J Pediatr. 2013 Nov;9(4):356-60 - PubMed
- Pediatrics. 2004 Sep;114(3):584-91 - PubMed
- Curr Med Chem. 2013;20(32):4060-9 - PubMed
- Environ Health Perspect. 2013 Aug;121(8):978-84 - PubMed
- Expert Opin Pharmacother. 2004 Mar;5(3):691-8 - PubMed
- Behav Brain Res. 2011 Sep 30;223(1):107-18 - PubMed
- J Biomed Biotechnol. 2012;2012:132876 - PubMed
- Metabolism. 2008 Oct;57 Suppl 2:S2-5 - PubMed
- Acta Neurobiol Exp (Wars). 2012;72(2):113-53 - PubMed
- Ann N Y Acad Sci. 1995 May 31;754:377-82 - PubMed
- Environ Health Perspect. 2005 Aug;113(8):1015-21 - PubMed
- Int J Environ Res Public Health. 2013 Aug 20;10(8):3771-800 - PubMed
- Toxicol Environ Chem. 2011 Feb;93(1-2):396-405 - PubMed
- Drug Saf. 2006;29(5):375-84 - PubMed
- Pediatrics. 2011 Jun;127(6):1034-42 - PubMed
- Neurotoxicol Teratol. 2012 Nov-Dec;34(6):592-7 - PubMed
- Cerebellum. 2012 Jun;11(2):575-86 - PubMed
- J Neurol Sci. 2008 Aug 15;271(1-2):110-8 - PubMed
- Neuro Endocrinol Lett. 2006 Aug;27(4):401-13 - PubMed
- PLoS Biol. 2008 Jul 1;6(7):e159 - PubMed
- Pediatrics. 1997 Jun;99(6):765-73 - PubMed
- Pediatrics. 2008 Feb;121(2):e208-14 - PubMed
- J Pediatr. 2000 May;136(5):679-81 - PubMed
- J Neurosci. 2010 Dec 15;30(50):16832-44 - PubMed
- Eur J Neurosci. 2011 Feb;33(3):521-9 - PubMed
- Drug Saf. 2002;25(3):145-52 - PubMed
- Pediatr Infect Dis J. 2004 Apr;23(4):287-94 - PubMed
- Pediatrics. 2001 May;107(5):1147-54 - PubMed
- Scand J Work Environ Health. 1985 Jun;11(3 Spec No):145-54 - PubMed
- Medicina (B Aires). 2013;73 Suppl 1:93-102 - PubMed
- Pediatrics. 2003 Nov;112(5):1039-48 - PubMed
- Bull World Health Organ. 2000;78(2):186-94 - PubMed
- Eur J Pediatr. 2007 Sep;166(9):935-41 - PubMed
- Mol Psychiatry. 2013 Oct;18(10):1106-18 - PubMed
- Neurotoxicology. 2013 Sep;38:1-8 - PubMed
- Biometals. 2009 Dec;22(6):1103-14 - PubMed
- Curr Opin Neurobiol. 2013 Apr;23(2):261-8 - PubMed
- AJNR Am J Neuroradiol. 2011 Feb;32(2):323-30 - PubMed
- MMWR Recomm Rep. 1991 Nov 22;40(RR-13):1-25 - PubMed
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