Display options
Cite
Oh YL, Yoon MS, Suh DS, et al. Changes in bone density after cancer treatment in patients with cervical and endometrial cancer. J Cancer. 2015;6(1):82-9doi: 10.7150/jca.10679.
Oh, Y. L., Yoon, M. S., Suh, D. S., Kim, A., Kim, M. J., Lee, J. Y., Song, Y. J., Ji, Y. I., Kim, K. H., & Chun, S. (2015). Changes in bone density after cancer treatment in patients with cervical and endometrial cancer. Journal of Cancer, 6(1), 82-9. https://doi.org/10.7150/jca.10679
Oh, Young Lim, et al. "Changes in bone density after cancer treatment in patients with cervical and endometrial cancer." Journal of Cancer vol. 6,1 (2015): 82-9. doi: https://doi.org/10.7150/jca.10679
Oh YL, Yoon MS, Suh DS, Kim A, Kim MJ, Lee JY, Song YJ, Ji YI, Kim KH, Chun S. Changes in bone density after cancer treatment in patients with cervical and endometrial cancer. J Cancer. 2015 Jan 01;6(1):82-9. doi: 10.7150/jca.10679. eCollection 2015. PMID: 25553092; PMCID: PMC4278918.
Copy Download .nbib Format: NLM
Share it on

J Cancer. 2015 Jan 01;6(1):82-9. doi: 10.7150/jca.10679. eCollection 2015.

Changes in bone density after cancer treatment in patients with cervical and endometrial cancer.

Journal of Cancer

Young Lim Oh, Man Soo Yoon, Dong Soo Suh, Ari Kim, Min Joung Kim, Ji Young Lee, Yong Jung Song, Yong Il Ji, Ki Hyung Kim, Sungwook Chun

Affiliations

  1. 1. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Republic of Korea;
  2. 2. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea;
  3. 3. Department of Obstetrics and Gynecology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea;
  4. 4. Department of Obstetrics and Gynecology, Catholic University School of Medicine, Seoul, Republic of Korea;
  5. 5. Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea;
  6. 6. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Republic of Korea;
  7. 7. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Republic of Korea.

PMID: 25553092 PMCID: PMC4278918 DOI: 10.7150/jca.10679

Abstract

OBJECTIVE: This study aimed to evaluate the impact of cancer treatment on bone mineral density (BMD) in the lumbar spine (LS) and femur in the postmenopausal women with cervical or endometrial cancer without bone metastasis compared to normal control postmenopausal women.

METHODS: We retrospectively evaluated the BMD data in the LS, femur neck (FN) and trochanter (FT) by dual-energy X-ray absorptiometry and laboratory data of bone turnover markers at baseline and after one year in 130 patients with cervical cancer, 68 patients with endometrial cancer, and 225 healthy controls.

RESULTS: There were no significant differences in the T-scores of basal BMD in LS and femur between patients with endometrial cancer and controls, and only T-score of basal BMD at the fourth lumbar vertebra (L4) was significantly lower in patients with cervical cancer compared to controls. One year later, T-scores of BMD at all LS sites and FN in patients with cervical cancer and T-scores of BMD at L3, L4, FN, and FT in those with endometrial cancer after cancer treatment were significantly lower compared to controls. Lower proportions of normal BMD at all skeletal sites except L2 in patients with endometrial cancer and those at L1, L4, and FN in patients with cervical cancer were observed compared to controls after cancer treatment.

CONCLUSIONS: Our results suggest that cancer treatment increase bone loss in postmenopausal women with cervical and endometrial cancer.

Keywords: Bone mineral density; Cervical cancer; Endometrial cancer; Osteoporosis.

References

  1. Jpn J Clin Oncol. 2002 Oct;32(10):422-4 - PubMed
  2. Am J Health Syst Pharm. 2006 Mar 1;63(5):419-30 - PubMed
  3. Cancer Res. 1983 Jan;43(1):403-7 - PubMed
  4. Oncologist. 2008 Feb;13(2):187-95 - PubMed
  5. Curr Opin Endocrinol Diabetes Obes. 2007 Dec;14(6):442-5 - PubMed
  6. J Obstet Gynaecol Res. 2009 Apr;35(2):335-8 - PubMed
  7. Biochem Biophys Res Commun. 1987 Jul 31;146(2):672-8 - PubMed
  8. NIH Consens Statement. 2000 Mar 27-29;17(1):1-45 - PubMed
  9. J Clin Oncol. 2000 Apr;18(7):1570-93 - PubMed
  10. Endocr Rev. 1995 Feb;16(1):87-116 - PubMed
  11. Menopause. 2010 Mar;17 (2):416-20 - PubMed
  12. Obstet Gynecol. 1991 Oct;78(4):689-92 - PubMed
  13. J Bone Miner Res. 1994 Aug;9(8):1137-41 - PubMed
  14. J Bone Miner Res. 1990 Feb;5(2):105-13 - PubMed
  15. Radiology. 1975 Dec;117(3 Pt 1):677-85 - PubMed
  16. Int J Cancer. 2008 Apr 15;122(8):1879-84 - PubMed
  17. Endocr Connect. 2012 Nov 19;2(1):11-7 - PubMed
  18. J Clin Endocrinol Metab. 1982 Aug;55(2):219-27 - PubMed
  19. Science. 1987 Aug 21;237(4817):893-6 - PubMed
  20. Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):1183-8 - PubMed
  21. J Clin Invest. 1987 Dec;80(6):1803-7 - PubMed
  22. Clin Chem. 1995 Oct;41(10):1489-94 - PubMed
  23. Am J Obstet Gynecol. 2006 Feb;194(2 Suppl):S3-11 - PubMed
  24. N Engl J Med. 1975 Dec 18;293(25):1278-83 - PubMed

Publication Types