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Anantha RV, Jegatheswaran J, Pepe DL, et al. Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study. CMAJ Open. 2014;2(4):E352-9doi: 10.9778/cmajo.20140018.
Anantha, R. V., Jegatheswaran, J., Pepe, D. L., Priestap, F., Delport, J., Haeryfar, S. M., McCormick, J. K., & Mele, T. (2014). Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study. CMAJ open, 2(4), E352-9. https://doi.org/10.9778/cmajo.20140018
Anantha, Ram Venkatesh, et al. "Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study." CMAJ open vol. 2,4 (2014): E352-9. doi: https://doi.org/10.9778/cmajo.20140018
Anantha RV, Jegatheswaran J, Pepe DL, Priestap F, Delport J, Haeryfar SM, McCormick JK, Mele T. Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study. CMAJ Open. 2014 Oct 01;2(4):E352-9. doi: 10.9778/cmajo.20140018. eCollection 2014 Oct. PMID: 25553328; PMCID: PMC4270209.
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CMAJ Open. 2014 Oct 01;2(4):E352-9. doi: 10.9778/cmajo.20140018. eCollection 2014 Oct.

Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study.

CMAJ open

Ram Venkatesh Anantha, Januvi Jegatheswaran, Daniel Luke Pepe, Fran Priestap, Johan Delport, S M Mansour Haeryfar, John K McCormick, Tina Mele

Affiliations

  1. Division of General Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont.
  2. Schulich School of Medicine and Dentistry, Western University, London, Ont.
  3. Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont.
  4. Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ont.
  5. Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont.
  6. Division of General Surgery, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont. ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ont. ; Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ont.

PMID: 25553328 PMCID: PMC4270209 DOI: 10.9778/cmajo.20140018

Abstract

INTRODUCTION: Staphylococcus aureus bacteremia is associated with significant morbidity and mortality. Given the paucity of recent Canadian data, we estimated the mortality rate associated with S. aureus bacteremia in a tertiary care hospital and identified risk factors associated with mortality.

METHODS: We retrospectively reviewed the records of adults with S. aureus bacteremia admitted to a tertiary care centre in southwestern Ontario between 2008 and 2012. Cox regression analysis was used to evaluate associations between predictor variables and all-cause, in-hospital, and 90-day postdischarge mortality.

RESULTS: Of the 925 patients involved in the study, 196 (21.2%) died in hospital and 62 (6.7%) died within 90 days after discharge. Risk factors associated with in-hospital and all-cause mortality included age, sepsis (adjusted hazard ratio [adjusted HR] 1.49, 95% confidence interval [CI] 1.08-2.06, p = 0.02), admission to the intensive care unit (adjusted HR 3.78, 95% CI 2.85-5.02, p < 0.0001), hepatic failure (adjusted HR 3.36, 95% CI 1.91-5.90, p < 0.0001) and metastatic cancer (adjusted HR 2.58, 95% CI 1.77-3.75, p < 0.0001). Methicillin resistance, hepatic failure, cerebrovascular disease, chronic obstructive pulmonary disease and metastatic cancer were associated with postdischarge mortality.

INTERPRETATION: The all-cause mortality rate in our cohort was 27.9%. Identification of predictors of mortality may guide empiric therapy and provide prognostic clarity for patients with S. aureus bacteremia.

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