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Yapca OE, Borekci B, Turan MI, et al. The effect of agomelatine on oxidative stress induced with ischemia/reperfusion in rat ovaries. Adv Clin Exp Med. 2014;23(5):715-21doi: 10.17219/acem/37227.
Yapca, O. E., Borekci, B., Turan, M. I., & Gulapoglu, M. (2014). The effect of agomelatine on oxidative stress induced with ischemia/reperfusion in rat ovaries. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 23(5), 715-21. https://doi.org/10.17219/acem/37227
Yapca, Omer E, et al. "The effect of agomelatine on oxidative stress induced with ischemia/reperfusion in rat ovaries." Advances in clinical and experimental medicine : official organ Wroclaw Medical University vol. 23,5 (2014): 715-21. doi: https://doi.org/10.17219/acem/37227
Yapca OE, Borekci B, Turan MI, Gulapoglu M. The effect of agomelatine on oxidative stress induced with ischemia/reperfusion in rat ovaries. Adv Clin Exp Med. 2014 Sep-Oct;23(5):715-21. doi: 10.17219/acem/37227. PMID: 25491684.
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Adv Clin Exp Med. 2014 Sep-Oct;23(5):715-21. doi: 10.17219/acem/37227.

The effect of agomelatine on oxidative stress induced with ischemia/reperfusion in rat ovaries.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Omer E Yapca, Bunyamin Borekci, Mehmet I Turan, Mine Gulapoglu

Affiliations

  1. Obstetrics and Gynecology, Sorgun State Hospital, Yozgat, Turkey.
  2. Department of Obstetrics and Gynecology, Ataturk University, Erzurum, Turkey.
  3. Department of Pediatrics, Ataturk University, Erzurum, Turkey.
  4. Department of Biochemistry, Ataturk University, Erzurum, Turkey.

PMID: 25491684 DOI: 10.17219/acem/37227

Abstract

BACKGROUND: Ovarian ischemia and reperfusion can lead to serious and irreversible health problems.

OBJECTIVES: The aim of this study is to investigate the protective effect of agomelatine against ovarian ischemia/ /reperfusion injury in rats using biochemical methods.

MATERIAL AND METHODS: Thirty female rats were divided into three groups (the number of animals in each group = 10), a control group in which ischemia/reperfusion was established (IRC), an ischemia/reperfusion + agomelatine (IRA) group and a healthy group given a sham operation (SG). Total glutathione (tGSH) and malondialdehyde (MDA) levels and glutathione peroxidase.

RESULTS: Biochemical results revealed MDA levels of 19.1 ± 2.03, 5.8 ± 1.5 and 5.5 ± 1.4 µmol/g protein in ovarian tissue in the IRC, IRA and SG groups, respectively. MPO activity in the IRC, IRA and SG groups was 7.87 ± 2.7, 4.0 ± 2.0 and 3.0 ± 1.0 U/g protein, respectively. tGSH levels were 1.87 ± 1.13, 4.37 ± 1.4 and 5.87 ± 1.64 nmol/g protein, respectively. GPx activity in the IRC, IRA and SG groups was 7.37 ± 1.68, 18.6 ± 3 and 17.75 ± 3.2 U/g protein, and SOD activity 31.1 ± 2.9, 45.3 ± 3.7 and 54 ± 4.2 U/g protein, respectively. The level of 8-OH/ /Gua, a product of DNA damage, was 2.18 ± 0.2 pmol/L in the IRC group, 1.28 ± 0.2 pmol/L in the IRA group and 0.93 ± 0.01 pmol/L in the SG group.

CONCLUSIONS: Agomelatine prevented ovarian ischemia/reperfusion injury.

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