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Lee HM, Lee SH, Yang IH, et al. Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation. Endocrinol Metab (Seoul). 2015;30(3):395-401doi: 10.3803/EnM.2015.30.3.395.
Lee, H. M., Lee, S. H., Yang, I. H., Hwang, I. K., Hwang, Y. C., Ahn, K. J., Chung, H. Y., Hwang, H. J., & Jeong, I. K. (2015). Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation. Endocrinology and metabolism (Seoul, Korea), 30(3), 395-401. https://doi.org/10.3803/EnM.2015.30.3.395
Lee, Hyae Min, et al. "Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation." Endocrinology and metabolism (Seoul, Korea) vol. 30,3 (2015): 395-401. doi: https://doi.org/10.3803/EnM.2015.30.3.395
Lee HM, Lee SH, Yang IH, Hwang IK, Hwang YC, Ahn KJ, Chung HY, Hwang HJ, Jeong IK. Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation. Endocrinol Metab (Seoul). 2015 Sep;30(3):395-401. doi: 10.3803/EnM.2015.30.3.395. Epub 2015 Sep 22. PMID: 25491785; PMCID: PMC4595366.
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Endocrinol Metab (Seoul). 2015 Sep;30(3):395-401. doi: 10.3803/EnM.2015.30.3.395. Epub 2015 Sep 22.

Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation.

Endocrinology and metabolism (Seoul, Korea)

Hyae Min Lee, Sun Hee Lee, In Ho Yang, In Kyoung Hwang, You Cheol Hwang, Kyu Jeung Ahn, Ho Yeon Chung, Hui Jeong Hwang, In Kyung Jeong

Affiliations

  1. Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
  2. Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
  3. Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea. [email protected].

PMID: 25491785 PMCID: PMC4595366 DOI: 10.3803/EnM.2015.30.3.395

Abstract

The leading cause of morbidity and mortality in patients with acromegaly is cardiovascular complications. Myocardial exposure to excessive growth hormone can cause ventricular hypertrophy, hypertension, arrhythmia, and diastolic dysfunction. However, congestive heart failure as a result of systolic dysfunction is observed only rarely in patients with acromegaly. Most cases of acromegaly exhibit high levels of serum insulin-like growth factor-1 (IGF-1). Acromegaly with normal IGF-1 levels is rare and difficult to diagnose. Here, we report a rare case of an acromegalic patient whose first clinical manifestation was severe congestive heart failure, despite normal IGF-1 levels. We diagnosed acromegaly using a glucose-loading growth hormone suppression test. Cardiac function and myocardial hypertrophy improved 6 months after transsphenoidal resection of a pituitary adenoma.

Keywords: Acromegaly; Heart failure; Insulin-like growth factor I

References

  1. J Clin Endocrinol Metab. 2004 Nov;89(11):5308-13 - PubMed
  2. Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):617-21 - PubMed
  3. Arch Intern Med. 1981 Nov;141(12):1625-7 - PubMed
  4. Indian J Endocrinol Metab. 2012 Nov;16(6):987-90 - PubMed
  5. J Endocrinol Invest. 2003;26(10 Suppl):27-35 - PubMed
  6. Mol Vis. 2011;17:2318-24 - PubMed
  7. Clin Endocrinol (Oxf). 2001 Sep;55(3):307-13 - PubMed
  8. Int J Cardiol. 2013 Sep 1;167(5):1712-8 - PubMed
  9. Endocr J. 2007 Aug;54(4):537-41 - PubMed
  10. Tohoku J Exp Med. 2008 Dec;216(4):325-9 - PubMed

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