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Berdnikova DV, Fedorova OA, Tulyakova EV, et al. Interaction of crown ether-annelated styryl dyes with double-stranded DNA. Photochem Photobiol. 2015;91(3):723-31doi: 10.1111/php.12405.
Berdnikova, D. V., Fedorova, O. A., Tulyakova, E. V., Li, H., Kölsch, S., & Ihmels, H. (2015). Interaction of crown ether-annelated styryl dyes with double-stranded DNA. Photochemistry and photobiology, 91(3), 723-31. https://doi.org/10.1111/php.12405
Berdnikova, Daria V, et al. "Interaction of crown ether-annelated styryl dyes with double-stranded DNA." Photochemistry and photobiology vol. 91,3 (2015): 723-31. doi: https://doi.org/10.1111/php.12405
Berdnikova DV, Fedorova OA, Tulyakova EV, Li H, Kölsch S, Ihmels H. Interaction of crown ether-annelated styryl dyes with double-stranded DNA. Photochem Photobiol. 2015 May-Jun;91(3):723-31. doi: 10.1111/php.12405. Epub 2015 Jan 23. PMID: 25524445.
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Photochem Photobiol. 2015 May-Jun;91(3):723-31. doi: 10.1111/php.12405. Epub 2015 Jan 23.

Interaction of crown ether-annelated styryl dyes with double-stranded DNA.

Photochemistry and photobiology

Daria V Berdnikova, Olga A Fedorova, Elena V Tulyakova, Haixing Li, Sarah Kölsch, Heiko Ihmels

Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia; Department Chemie-Biologie, Universität Siegen, Organische Chemie II, Siegen, Germany.

PMID: 25524445 DOI: 10.1111/php.12405

Abstract

DNA-binding properties of 15-crown-5-derived mono- and bis-styryl dyes were investigated in the presence of calf thymus DNA. To access the factors that influence the DNA association in the series of these ligands, the structure of the molecules was varied by either changing size of the heterocyclic moiety or altering the position of the styryl substituents. The major binding mode for the monostyryl dyes is intercalation. Notably, binding of the dyes to the nucleic acids leads to a fluorescence enhancement by a factor of up to 54. Therefore, these cationic styryl derivatives may be applied as fluorescent "light-up" probes for DNA detection.

© 2014 The American Society of Photobiology.

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