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Wazir U, Manson A, Mokbel K. Towards optimal management of the axilla in the context of a positive sentinel node biopsy in early breast cancer. World J Clin Oncol. 2014;5(5):792-4doi: 10.5306/wjco.v5.i5.792.
Wazir, U., Manson, A., & Mokbel, K. (2014). Towards optimal management of the axilla in the context of a positive sentinel node biopsy in early breast cancer. World journal of clinical oncology, 5(5), 792-4. https://doi.org/10.5306/wjco.v5.i5.792
Wazir, Umar, et al. "Towards optimal management of the axilla in the context of a positive sentinel node biopsy in early breast cancer." World journal of clinical oncology vol. 5,5 (2014): 792-4. doi: https://doi.org/10.5306/wjco.v5.i5.792
Wazir U, Manson A, Mokbel K. Towards optimal management of the axilla in the context of a positive sentinel node biopsy in early breast cancer. World J Clin Oncol. 2014 Dec 10;5(5):792-4. doi: 10.5306/wjco.v5.i5.792. PMID: 25493217; PMCID: PMC4259941.
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World J Clin Oncol. 2014 Dec 10;5(5):792-4. doi: 10.5306/wjco.v5.i5.792.

Towards optimal management of the axilla in the context of a positive sentinel node biopsy in early breast cancer.

World journal of clinical oncology

Umar Wazir, Aisling Manson, Kefah Mokbel

Affiliations

  1. Umar Wazir, Aisling Manson, Kefah Mokbel, The London Breast Institute, Princess Grace Hospital, London W1U 5NY, United Kingdom.

PMID: 25493217 PMCID: PMC4259941 DOI: 10.5306/wjco.v5.i5.792

Abstract

The sentinel lymph node biopsy (SLNB) was initially pioneered for staging melanoma in 1994 and it has been subsequently validated by several trials, and has become the new standard of care for patients with clinically node negative invasive breast cancer. The focussed examination of fewer lymph nodes in addition to improvements in histopathological and molecular analysis has increased the rate at which micrometastases and isolated tumour cells are identified. In this article we review the literature regarding the optimal management of the axilla when the SLNB is positive for metastatic disease based on level 1 evidence derived from randomised clinical trials.

Keywords: Axillary dissection; Axillary radiotherapy; Early breast cancer; Evidence-based medicine; Sentinel lymph node biopsy

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