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Citó MC, Silva MI, Santos LK, et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2014;48(1):57-64doi: 10.1590/1414-431x20144215.
Citó, M. C., Silva, M. I., Santos, L. K., Fernandes, M. L., Melo, F. H., Aguiar, J. A., Lopes, I. S., Sousa, P. B., Vasconcelos, S. M., Macêdo, D. S., & Sousa, F. C. (2015). Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 48(1), 57-64. https://doi.org/10.1590/1414-431x20144215
Citó, M C O, et al. "Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system." Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas vol. 48,1 (2015): 57-64. doi: https://doi.org/10.1590/1414-431x20144215
Citó MC, Silva MI, Santos LK, Fernandes ML, Melo FH, Aguiar JA, Lopes IS, Sousa PB, Vasconcelos SM, Macêdo DS, Sousa FC. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2015 Jan;48(1):57-64. doi: 10.1590/1414-431x20144215. Epub 2014 Nov 07. PMID: 25493384; PMCID: PMC4288494.
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Braz J Med Biol Res. 2015 Jan;48(1):57-64. doi: 10.1590/1414-431x20144215. Epub 2014 Nov 07.

Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

M C O Citó, M I G Silva, L K X Santos, M L Fernandes, F H C Melo, J A C Aguiar, I S Lopes, P B Sousa, S M M Vasconcelos, D S Macêdo, F C F Sousa

Affiliations

  1. Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.

PMID: 25493384 PMCID: PMC4288494 DOI: 10.1590/1414-431x20144215

Abstract

Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H. gordonii extract (25 and 50 mg/kg, po) to mice exposed to a forced swimming test (FST). Neurochemical analysis of brain monoamines was also carried out to determine the involvement of the monoaminergic system on these effects. Acute administration of H. gordonii decreased the immobility of mice in the FST without accompanying changes in general activity in the open-field test during acute treatment, suggesting an antidepressant-like effect. The anti-immobility effect of H. gordonii was prevented by pretreatment of mice with PCPA [an inhibitor of serotonin (5-HT) synthesis], NAN-190 (a 5-HT1A antagonist), ritanserin (a 5-HT2A/2C antagonist), ondansetron (a 5-HT3A antagonist), prazosin (an α1-adrenoceptor antagonist), SCH23390 (a D1 receptor antagonist), yohimbine (an α2-adrenoceptor antagonist), and sulpiride (a D2 receptor antagonist). A significant increase in 5-HT levels in the striatum was detected after acute administration, while 5-HT, norepinephrine and dopamine were significantly elevated after chronic treatment. Results indicated that H. gordonii possesses antidepressant-like activity in the FST by altering the dopaminergic, serotonergic, and noradrenergic systems.

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