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Gupta S, Ellis SE, Ashar FN, et al. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun. 2014;5:5748doi: 10.1038/ncomms6748.
Gupta, S., Ellis, S. E., Ashar, F. N., Moes, A., Bader, J. S., Zhan, J., West, A. B., & Arking, D. E. (2014). Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nature communications, 55748. https://doi.org/10.1038/ncomms6748
Gupta, Simone, et al. "Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism." Nature communications vol. 5 (2014): 5748. doi: https://doi.org/10.1038/ncomms6748
Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J, West AB, Arking DE. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun. 2014 Dec 10;5:5748. doi: 10.1038/ncomms6748. PMID: 25494366; PMCID: PMC4270294.
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Nat Commun. 2014 Dec 10;5:5748. doi: 10.1038/ncomms6748.

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.

Nature communications

Simone Gupta, Shannon E Ellis, Foram N Ashar, Anna Moes, Joel S Bader, Jianan Zhan, Andrew B West, Dan E Arking

Affiliations

  1. Department of Medicine, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  2. 1] Department of Medicine, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  3. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  4. Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

PMID: 25494366 PMCID: PMC4270294 DOI: 10.1038/ncomms6748

Abstract

Recent studies of genomic variation associated with autism have suggested the existence of extreme heterogeneity. Large-scale transcriptomics should complement these results to identify core molecular pathways underlying autism. Here we report results from a large-scale RNA sequencing effort, utilizing region-matched autism and control brains to identify neuronal and microglial genes robustly dysregulated in autism cortical brain. Remarkably, we note that a gene expression module corresponding to M2-activation states in microglia is negatively correlated with a differentially expressed neuronal module, implicating dysregulated microglial responses in concert with altered neuronal activity-dependent genes in autism brains. These observations provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism.

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