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Rajan P, Baramappa R, Rao NM, et al. Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trail. J Clin Diagn Res. 2014;8(12):ZC11-4doi: 10.7860/JCDR/2014/8848.5237.
Rajan, P., Baramappa, R., Rao, N. M., Pavaluri, A. K., P, I., & Rahaman, S. M. (2014). Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trail. Journal of clinical and diagnostic research : JCDR, 8(12), ZC11-4. https://doi.org/10.7860/JCDR/2014/8848.5237
Rajan, Padma, et al. "Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trail." Journal of clinical and diagnostic research : JCDR vol. 8,12 (2014): ZC11-4. doi: https://doi.org/10.7860/JCDR/2014/8848.5237
Rajan P, Baramappa R, Rao NM, Pavaluri AK, P I, Rahaman SM. Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trail. J Clin Diagn Res. 2014 Dec;8(12):ZC11-4. doi: 10.7860/JCDR/2014/8848.5237. Epub 2014 Dec 05. PMID: 25654021; PMCID: PMC4316327.
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J Clin Diagn Res. 2014 Dec;8(12):ZC11-4. doi: 10.7860/JCDR/2014/8848.5237. Epub 2014 Dec 05.

Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trail.

Journal of clinical and diagnostic research : JCDR

Padma Rajan, Radhika Baramappa, Nagashree Medanda Rao, Arvind Kumar Pavaluri, Indeevar P, Syed Mouaz Ur Rahaman

Affiliations

  1. Professor & Head of Department, Department of Periodontics, Coorg Institute of Dental Sciences , Virajpet, Karnataka, India .
  2. Senior Lecturer, Department of Periodontics, Coorg Institute of Dental Sciences , Virajpet, Karnataka, India .
  3. Professor, Department of Periodontics, St. Joseph Dental college , Eluru, Andhra Pradesh, India .
  4. Reader, Department of Periodontics, St. Joseph Dental college , Eluru, Andhra Pradesh, India .
  5. Senior Lecturer, Department of Periodontics, Eluru, Andhra Pradesh, India .
  6. Post Graduate Student, Coorg Institute of Dental Sciences , Virajpet, Karnataka, India .

PMID: 25654021 PMCID: PMC4316327 DOI: 10.7860/JCDR/2014/8848.5237

Abstract

AIM: AIM of the present study was to evaluate the adjunctive effect of local application of hyaluronon gel following scaling and root planing (SRP) in chronic periodontitis patients.

MATERIALS AND METHODS: In this randomized split mouth study 33 subjects with chronic periodontitis were evaluated after full mouth SRP. In the test sites hyaluronon gel was applied immediately after SRP and one week post therapy, the control sites were treated with SRP alone. Bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline, 4 wk and 12 wk.

RESULTS: Significant reduction in BOP scores was observed in both the groups at 12weeks (p<0.001). The hyaluronon group showed a greater reduction in BOP (p<0.001). In the hyaluronon group the mean PPD at baseline was 6.33±0.09 which reduced to 2.49±0.51 at 12 weeks which was statistically significant (p<0.001). In the control group the mean PPD at baseline was 6.09±1.26 which reduced to 4.36±1.29 at 12 weeks which was statistically significant (p<0.001). The CAL measurements showed a significant difference between the groups (p<0.001) at 12 wk post therapy.

CONCLUSION: Hyaluronic Acid (HA) has a beneficial effect on periodontal health in patients with chronic Periodontitis. HA appears to be a suitable candidate as an adjunct to SRP in chronic periodontitis patients.

Keywords: Chronic periodontitis; Clinical trial; Hyaluronic acid; Root planing

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